The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his ...
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources ...
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over ...
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial ...
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study ...
[Kuhbacher et al., The Journal of Biological Chemistry 2012]
Actin polymerization precedes OCRL recruitment to L. monocytogenes vacuoles. Microscopy analysis of the distribution of endogenous OCRL, EGFP-OCRL-a, and actin in cells infected by L. monocytogenes P14.PrfA*. Bar: 10_m(inset bar: 1_m).
[Pizarro-Cerda et al., Nature Cell Biology 2004]
Main steps in phosphoinositide synthesis and degradation, showing some of the enzymes that catalyse the reactions and the steps subverted by bacterial pathogens. Yersinia species induce activation of a PIP(5)K to promote PtdIns(4,5)P2 formation; Listeria monocytogenes and UPEC promote the activity of the class I PI(3)K to generate PtdIns(3,4,5)P3, whereas EPEC blocks its activity; Mycobacterium tuberculosis, blocks a class III PI(3)K involved in the formation of PtdIns(3)P; Shigella flexneri translocates into host cells the bacterial enzyme IpgD that dephosphorylates PtdIns(4,5)P2 into PtdIns(5)P; Salmonella enterica also translocates a bacterial effector, SigD/SopB, that has phosphatidylinositol polyphosphate phosphatase activity and it has been proposed to dephosphorylate the 5'-phosphate from PtdIns(3,5)P2 and PtdIns(3,4,5)P3; SigD/SopB is also implicated in the turnover of PtdIns(4,5)P2, but the precise PtdIns(4,5)P2 hydrolysis site remains to be determined. SigD/SopB additionally has inositol phosphate phosphatase activity (not shown in the diagram).
Updated on 13/05/2014
Unité Interactions Bactéries-Cellules
INSERM U604 INRA USC2020
25, Rue du Docteur Roux
75724 Paris Cedex 15 FRANCE
Phone: + 33 (1) 45 68 88 41
Secretary: + 33 (1) 40 61 30 32
Fax: + 33 (1) 45 68 87 06
Our laboratory is located on the ground floor at the 53C entrance of the Roux Building (25, rue du Docteur Roux)
The metro stations Pasteur (line 6) and Volontaires (line 12) are within a 5 min walking distance from the Pasteur Institute.
The bus stop Pasteur (bus 95, towards Porte de Vanves) is located next to the Pasteur Institute main entrance.