The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
[Photo: H. Bierne, in Cellular Microbiology, American Society for Microbiology]
Mammalian cells infected by Listeria monocytogenes (red) in the process of polymerizing actin (green).
[Jasnin et al., PNAS 2013]
Hollow Listeria cytoplasmic comet tail contains closely packed parallel filaments. a) Slice through the tomogram of a cytoplasmic comet tail (tail) in a PtK2 cell (cytoplasm is indicated by cyt) infected by Listeria. b) (Scale bar: 200 nm.) Distribution of XY-filaments (b) and Z-filaments (c) in the XZ plane, projected over the Y axis. The color scale ranges from high occurrence (red) to low occurrence (blue) (same color code in all relevant panels). f) XY-filaments projected into the XY plane. The color of the filaments corresponds to their anglewith respect to the Y axis: 0–15° (blue), 15– 30° (green), 30–45° (red). The cell wall of the bacterium is shown in gray.
[Cossart et al., Microbes and infection 2008]
Actin-based motility. a) Cell infected with Listeria and observed by immunofluorescence (green: actin; red: bacteria; blue: nucleus). b) Schematic representation of actin polymerization by various pathogens.
[Pizarro-Cerda et al., Journal of Pathology 2006]
Polymerization of actin comet tails by ActA. a) The proline-rich sequence of ActA recruits VASP, which in turn
recruits profilin and actin monomers that will be polymerized by the Arp2/3 complex, leading to the formation of actin comet tails that power the movement of L. monocytogenes in the host cell cytoplasm. b) Immunofluorescence showing the actin cytoskeleton (green) of kangaroo PTK2 and the polymerization of actin comet tails by L. monocytogenes (red).
[Cossart et al., Current Opinion in Immunology 2001]
Model of actin assembly induced by ActA. The ActA is represented as a dimer and its polar distribution at the bacterial surface is represented as a hatched area. The bacterium is moving from left to right as indicated by the arrow.
[Gouin et al., Journal of Cell Science 1999]
Electron microscopy of myosin S1 decorated actin tails of R. conorii a), L. monocytogenes b) and S. flexneri e) in HEp2 cells. The two boxes in b and e are shown at higher magnification in c and d, and in f and g, respectively. Bars: a,b) 0.2 µm; e) 0.4 µm; c,d,f,g) 50 nm.
[Gouin et al., Journal of Cell Science 1999]
Electron microscopy of S1 myosin decorated actin tails of R. conoriia,b), L. monocytogenes c) and S. flexneri d) inside Hep2 cell protrusions. Bars, 0.5 µm.
Updated on 13/05/2014
Unité Interactions Bactéries-Cellules
INSERM U604 INRA USC2020
25, Rue du Docteur Roux
75724 Paris Cedex 15 FRANCE
Phone: + 33 (1) 45 68 88 41
Secretary: + 33 (1) 40 61 30 32
Fax: + 33 (1) 45 68 87 06
Our laboratory is located on the ground floor at the 53C entrance of the Roux Building (25, rue du Docteur Roux)
The metro stations Pasteur (line 6) and Volontaires (line 12) are within a 5 min walking distance from the Pasteur Institute.
The bus stop Pasteur (bus 95, towards Porte de Vanves) is located next to the Pasteur Institute main entrance.