Internalins

 

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[Bécavin et al, mBio 2014]

Internalins in EGD-e, EGD, and 10403S. (a) Schematic domain organization of the four family of EGD-e internalins. (b) inlH represents a fusion of the 5’ end of inlC2, encoding the internalin domain, with the 3’ end of inlD, encoding the B-repeats and the sorting signal. (c) Amino acid difference between InlH and InlC2.

 

 

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[Neves et al., Journal of Molecular Biology 2013]

Gallery of internalin structures. Despite the fact that InlK displays the common LRR region, it is the only one to harbor the two C-terminal Ig-like domains that could potentially act similar to pedestals that help project the N-terminal domains away from the surface of the bacterial cell. PDB access codes for the different structures depicted are 4FMZ (InlF), 1H6U (InlH), 4L3A (InlK), 3BZ5 (InlJ), 1O6V (InlA), 1M9S (InlB), and 1XEU (InlC).

 

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[Cossart, PNAS 2011]

Roles of InlA and InlB in vivo. (A) The species specificities of InlA and InlB. (B) Schematic representation of the barriers where InlA and InlB play a role in vivo. (C) Tridimensional structure of the InlA-E-cadherin and InlBMet cocrystals.

Updated on 13/05/2014

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Lab address

Unité Interactions Bactéries-Cellules

INSERM U604 INRA USC2020
Institut Pasteur
25, Rue du Docteur Roux
75724 Paris Cedex 15 FRANCE

 

Phone: + 33 (1) 45 68 88 41

Secretary: + 33 (1) 40 61 30 32

Fax: + 33 (1) 45 68 87 06

 

Our laboratory is located on the ground floor at the 53C entrance of the Roux Building (25, rue du Docteur Roux)

The metro stations Pasteur (line 6) and Volontaires (line 12) are within a 5 min walking distance from the Pasteur Institute.

The bus stop Pasteur (bus 95, towards Porte de Vanves) is located next to the Pasteur Institute main entrance.

For more information: Pasteur Institute Access and Paris Metro/Bus/Tram

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