The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
Our Unit investigates the molecular and cellular basis of the infection by Listeria monocytogenes, a model pathogen for the study of the intracellular parasitism. L. monocytogenes is responsible for severe foodborne infections. This bacterium is characterized by its ability to cross three host barriers -the intestinal, blood-brain or feto-placental barriers- and to invade several cell types in which it multiplies. L. monocytogenes moves in the cytosol of infected cells and spreads from cell to cell using an original propelling process; i.e. cell actin polymerization at one pole of the bacteria.
Our present activity focuses on: 1) the identification and characterization of new non-coding RNAs involved in virulence, as well as new RNA-mediated regulations; 2) the investigation of new molecular pathways involved in bacterial entry into host cells and cell-to-cell spread; 3) organelle dynamics during infection; 4) the systematic analysis of post-translational modifications of host molecules during infection, in particular SUMOylation; 5) chromatin remodeling upon infection; 6) the characterization of new bacterial virulence factors identified by post-genomic approaches or by their effect on cellular responses; and 7) in-depth understanding of the intestinal phase of the L. monocytogenes infection by analyzing the impact of commensals on L. monocytogenes growth and the bacterial effect on the intestinal tissue.
In many of these research themes, we try to generalize our findings to other bacterial models.
Since 2004, the "Unité des Interactions Bactéries-Cellules" (UIBC) is associated with Inserm (INSERM U604) and with INRA (INRA USC2020).