Comment notre cerveau forme-t-il et utilise-t-il des souvenirs distincts d’événements se ressemblant ? Des chercheurs de l’Institut Pasteur (Paris) ont associé des techniques d’imagerie et d’enregistrement du comportement pour mesurer l’activité des neurones dans l’hippocampe de souris. Ils ont ainsi observé que la région d’entrée de l’hippocampe décelait les moindres changements d’environnement familier / inconnu, et que la région de sortie, elle, pondérait ensuite ces informations pour guider les décisions comportementales.

Le National Institute of Allergy and Infectious Diseases (NIAID), appartenant aux National Institutes of Health (NIH) - ces institutions gouvernementales des États-Unis qui s'occupent de la recherche médicale et biomédicale -, a accordé 11 subventions pour mettre en place des centres de recherche sur les maladies infectieuses émergentes - Centers for Research in Emerging Infectious Diseases (CREID) -, dont un centre de coordination et le Pasteur International Center for Research on Emerging Infectious Diseases (PICREID), dirigé par Anav

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), has awarded 11 grants to establish the Centers for Research in Emerging Infectious Diseases (CREID), including a coordinating center. One of those centers, and the sole center coordinated by a non-American organization, is the Pasteur International Center for Research on Emerging Infectious Diseases (PICREID), headed by Anavaj Sakuntabhai at the Institut Pasteur in Paris.

How do we form and use distinct memories of resembling events? Scientists at the Institut Pasteur (Paris) have combined imaging and behavioral recording techniques to measure the activity of neurons in the hippocampus of mice. According to their observations, the input region of the hippocampus detects small changes between familiar and novel environments, while the output region then weights this information to guide behavioral decisions. This finding illustrates how the brain keeps the delicate balance between creating new memories and recalling existing ones.

Institut Pasteur's expertise in infectious diseases has made it one of the major players in research against Covid-19. For the 2020 Pasteurdon (the Institut Pasteur’s public fundraising campaign), a podcast in French has been recorded. Two Pasteurian researchers, Sylvie van der Werf and Arnaud Fontanet, talk about this pandemic and the Institut Pasteur's actions to fight the virus. They also explain how infectious diseases work and the factors behind the emergence of new diseases.

Antimicrobial resistance could become the leading cause of death in the world, with 10 million deaths in 2050, if nothing is done to prevent it. Today, 400,000 people die each year because of antibiotic resistance. The Institut Pasteur has made the study of bacterial resistance and the fight against resistant bacteria one of its priorities. On the occasion of Pasteurdon 2020 (the Institut Pasteur’s public fundraising campaign), Mathieu Vidard interviews two Pasteurian researchers, Paola Arimondo and Philippe Glaser, who both coordinate this line of research.

In 2018, 40,000 new cases of cancer were recorded in France, where this disease is the leading cause of death. Within the Institut Pasteur, more than 50 interdisciplinary teams are working on the subject. For the 2020 Pasteurdon (the Institut Pasteur’s public fundraising campaign), a podcast in French has been recorded. Two Pasteurian researchers, Sandrine Etienne-Manneville and Ludovic Deriano, are looking back at the definition of cancer, the challenges of research on the subject, screening and treatment options.

Neurology is an interdisciplinary field, in which research has evolved significantly in recent decades. At the Institut Pasteur, research is conducted on many subjects related to the brain such as degenerative diseases, memory, brain connectivity or sensory deficits. For the 2020 Pasteurdon (the Institut Pasteur’s public fundraising campaign), a podcast in French has been recorded. Two 'Pasteurian' researchers, Chiara Zurzolo and Pierre-Marie Lledo, explain the brain's function, from its place in the body to the role of synapses in neurodegenerative diseases.

For the 2020 Pasteurdon (the Institut Pasteur’s public fundraising campaign), listen to a podcast in French. Mathieu Vidard, presenter of "La Terre au carré" on France Inter (major French public radio channel and part of Radio France), discusses with two distinguished scientists from the Institut Pasteur: Christophe d’Enfert, scientific director and François-Xavier Weill, who is in charge of a research unit that includes two national reference center. Both explain the Institut Pasteur's role in monitoring the occurrence of epidemics and in health surveillance.

Hepatitis B is a viral infection that can be fatal. Most chronic forms are caused by mother-to-child transmission. To avoid this transmission, the World Health Organization (WHO) decided to add new recommendations to its existing guidelines. Yusuke Shimakawa, an expert at the Institut Pasteur in Paris, was given the task of producing two systematic reviews to help determine the nature of the new recommendations. He coordinated this research, with the help of WHO, by forming a team including two other Institut Pasteur scientists (Anna L.