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  • The three-dimensional structure of SUB1, Highly regulated therapeutic target shows promise in the search for new antimalarial treatments, © Jean-Christophe Barale, Institut Pasteur

    Press release | 10.09.2014

    Highly regulated therapeutic target shows promise in the search for new antimalarial treatments

    Artemisinin is currently the most effective malarial treatment available. However, the recent emergence in South-East Asia of artemisinin-resistant parasites strengthens the urgent need to identify a new generation of antimalarial drugs. In this context, scientists have determined the three-dimensional structure of a promising new therapeutic target for malaria: SUB1.

  • Neo-neurons in an adult brain, Pierre-Marie Lledo, Mental states control the integration of new neurons in the adult brain, © Institut Pasteur

    Press release | 02.09.2014

    Mental states control the integration of new neurons in the adult brain

    Although it has been known for several years that the adult brain is capable of producing new neurons, how these neurons are integrated into existing, functional nerve circuits has hitherto remained a mystery. Scientists have just shown that new neurons set up a denser network of connections with the rest of the brain in contexts of active (as opposed to passive) motivation and learning.

  • Ebola virus, The Institut Pasteur steps up its action against Ebola, © Institut Pasteur

    Press release | 01.09.2014

    The Institut Pasteur steps up its action against Ebola

    Ever since the Ebola virus was identified in Guinea in March 2014, the designated WHO Collaborating Centers within the Institut Pasteur and Institut Pasteur International Network have been assisting the international aid initiative via diagnostic support and epidemiological surveillance. Now, faced with the seriousness and spread of the epidemic, the Institut Pasteur and Institut Pasteur International Network are strengthening and coordinating their efforts in order to effectively fight the disease.

  • Potential strategies for limiting the hepatitis C epidemic in Egypt

    Press release | 28.08.2014

    Potential strategies for limiting the hepatitis C epidemic in Egypt

    In the fight against hepatitis C, directing preventive and curative interventions towards sufferers of chronic diseases requiring regular medical care would be an effective means of reducing transmission of the hepatitis C virus (HCV) in Egypt, and undoubtedly also in other countries with limited resources. This theory has arisen from a mathematical modeling study carried out as part of the ANRS 1211 study, conducted jointly by scientists at the Institut Pasteur, the CNAM and their fellow scientists in Egypt.

  • Streptococcus agalactiae in white blood cells (polynuclear neutrophils) in the cerebrospinal fluid of a child with meningitis (optical microscopy, Gram stain). © Claire Poyart, CNR-Strep (AP-HP, Inserm)

    Press release | 04.08.2014

    The emergence of neonatal group B streptococcal infections explained

    Scientists from the Institut Pasteur and the CNRS have recently revealed the cause behind the emergence in the 1960s of neonatal infections due to group B streptococcus. These findings prove that the sudden emergence of infections caused by this bacterium resulted from the widespread use of an antibiotic, tetracycline, from the 1950s onwards.

  • Can injuries to the skin be painless? National Buruli ulcer control Programme, Benin ©OMS

    Press release | 19.06.2014

    Can injuries to the skin be painless?

    When the body receives an injury to the skin, a signal is sent to the brain, which generates a sensation of pain. Researchers have studied lesions in patients with Buruli ulcer, a tropical disease. They show that, despite the extent and severity of these wounds, they are less painful than others that seem relatively minor (e.g. scratches, low-degree burns). They discovered an analgesic mechanism that limits the transmission of pain signals to the brain. An understanding of this mechanism may be useful in developing new drugs for pain relief.

     

  • Hair bundles of the auditory outer hair cells - Mild hearing impairment may indicate greater underlying problems - © Institut Pasteur

    Press release | 12.06.2014

    Mild hearing impairment may indicate greater underlying problems

    Scientists identified mice models that mimic high-frequency hearing impairment in humans. Their work sheds light on the anomalies causing the hearing impairment and could explain the pronounced masking effect experienced by some hearing-impaired individuals when trying to discriminate high-frequency sounds in noisy environments. The scientists suggest that more substantial auditory assessments would enable clinicians to improve diagnosis of these auditory impairments.

  • Découverte d'une mémoire immunitaire chez le foetus - Institut Pasteur

    Press release | 10.06.2014

    Immunological memory discovered in fetuses

    Scientists have recently demonstrated the existence of immunological memory cells in fetuses. These cells are developed in utero and are capable of producing an inflammatory-type immune response. The results of this study suggest that it may be possible to develop vaccine-induced immunological memory, during pregnancy and specific to the fetus, which would increase immunity in infants during the first months of life.

     

  • Directing stem cells fates - Institut Pasteur

    Press release | 23.05.2014

    Directing stem cells fates

    Researchers have discovered that the immediate environment of stem cells can have a strong influence on the fate of their descendants : they observed that the forces applied to stem cells during division influenced the likelihood that these dividing cells would produce two new stem cells, one stem cell and one specialized cell, or even two specialized cells. This study has major implications for the therapeutic use of stem cells: it suggests that, by controlling the composition and conditions in the microenvironment of the niche, it is possible to reproduce and retain stem cell properties in culture for subsequent use in transplants to repair damaged tissues.

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The Pasteur Museum is located at the Institut Pasteur, situated at: 25 rue du Docteur Roux 75015 Paris, France
 

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