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  • The Mycobacterium tuberculosis bacterium, causative agent of tuberculosis. Tuberculosis: a promising vaccine candidate. © Institut Pasteur

    Press release | 02.08.2016

    Tuberculosis: a promising vaccine candidate

    Scientists have published the results of their research into the action mechanisms of a promising experimental tuberculosis (TB) vaccine. BCG, the only currently approved TB vaccine, has been around for almost a century, but it is only partially effective and the protection it offers fades over time. Given the current emergence of adult TB cases in conjunction with the HIV epidemic and the rise in multidrug-resistant TB strains, the development of a new, more effective vaccine is a global health priority.

  • Anopheles stephensi infected by Plasmodium berghei

    Press release | 18.07.2016

    Malaria: a genetically attenuated parasite induces an effective, long-lasting immune response

    With nearly 3.2 billion people currently at risk of contracting malaria, scientists from the Institut Pasteur, the CNRS and Inserm have experimentally developed a live, genetically attenuated vaccine for Plasmodium, the parasite responsible for the disease. By identifying and deleting one of the parasite's genes, the scientists enabled it to induce an effective, long-lasting immune response in a mouse model. These findings were published in the Journal of Experimental Medicine on July 18, 2016.

  • Bacteriophages on the Escherichia coli bacterium. Phage therapy: fundamental action mechanisms revealed. © Institut Pasteur

    Press release | 07.07.2016

    Phage therapy: fundamental action mechanisms revealed

    Scientists identify for the first time the genetic and metabolic mechanisms underpinning the therapeutic action of a bacteriophage known for its therapeutic potential. Given the worrying rise in bacterial resistance to antibiotics and the difficulties in developing effective new molecules, there has been renewed interest within the scientific community in recent years in phage therapy, which makes use of these bacterial viruses.

  • A new adult-born neuron. The relentless dynamism of the adult brain. © Institut Pasteur/PM Lledo

    Press release | 30.06.2016

    The relentless dynamism of the adult brain

    Scientists were able to make real-time observations over a period of several months that reveal how new adult-born neurons are formed and evolve in the olfactory bulb of mice. They made the surprising discovery that there is constant structural plasticity in the connections established by these new neurons with the circuits into which they are recruited.

  • Anopheles gambiae mousquito. © Institut Pasteur/Paul Brey

    Press release | 23.06.2016

    Malaria - First global mapping of artemisinin resistance confirms definitively that resistance is confined to Southeast Asia and has not spread to sub-Saharan Africa

    The first global mapping of artemisinin resistance (the KARMA study) has definitively confirmed that resistance to the main drug currently used in the treatment of Plasmodium falciparum malaria is for the moment confined to Southeast Asia and has not spread to sub–Saharan Africa.

  • Antibodies that are effective against both dengue and Zika viruses. Institut Pasteur

    Press release | 23.06.2016

    Antibodies that are effective against both dengue and Zika viruses

    Scientists have identified antibodies that can efficiently neutralize both the dengue virus and the Zika virus. The description of the binding site for these antibodies on the viral envelope, identical for both viruses, could lead to the development of a universal vaccine that offers simultaneous protection against dengue and Zika virus disease.

  • Microscopy of a neuron. © Institut Pasteur/Christelle Durand

    Press release | 06.06.2016

    Identification of a therapeutic compound for a genetic form of autism spectrum disorders thanks to high throughput screening

    A team of researchers has highlighted the therapeutic potential of lithium in a patient with a rare form of autism spectrum disorder associated with SHANK3 gene mutation. This molecule, usually used to treat bipolar disorder, was identified thanks to high throughput screening of chemical compounds on human neurons derived from pluripotent stem cells, including those of the treated patient.

  • HIV virus particles. HIV: Identification of key immune response receptors in patients spontaneously controlling infection. © Institut Pasteur, Charles Dauguet

    Press release | 18.05.2016

    HIV: Identification of key immune response receptors in patients spontaneously controlling infection

    A small number of patients infected by HIV spontaneously control viral replication without antiretroviral therapy, and do not develop the disease. The ability of these rare patients, known as "HIV controllers", to suppress HIV replication appears to be down to a highly effective immune response. Scientists observed that CD4+ T immune cells in these patients were capable of recognizing tiny quantities of the virus.

  • Meningococcal disease: identification of a sexually transmitted variant

    Press release | 12.05.2016

    Meningococcal disease: identification of a sexually transmitted variant

    A study from the University of Würzburg (Germany) and the Institut Pasteur (France) elucidates the mechanisms of the emergence of an outbreak of meningococcal disease in men who have sex with men (MSM). These results are published in the open access journal PLOS ONE.  

  • Green monkey cells infected with Zika virus seen through a transmission electron microscope. Viral particles measure 40nm in diameter. How could Zika enter Europe? © Institut Pasteur

    Press release | 25.04.2016

    How could Zika enter Europe?

    Researchers at the Institut Pasteur have assessed the transmission potential of four populations of Aedes mosquitoes in circulation on the island of Madeira and southern France with a view to examining various possible scenarios for the introduction of Zika virus to Europe. Their work suggests that the Aedes aegypti mosquito present in Madeira is more likely to promote local transmission of Zika virus than Aedes albopictus. Consequently, it appears that the risk of a Zika epidemic in continental Europe is still low.

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The Pasteur Museum is located at the Institut Pasteur, situated at: 25 rue du Docteur Roux 75015 Paris, France
 

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