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  • Research | 10.10.2013

    Fine-tuning the approach to malaria and toxoplasmosis research

    A study carried out by teams from the Institut Pasteur, the Institut Cochin (Inserm, CNRS, Paris Descartes University), and the Wellcome Trust Centre for Molecular Parasitology at the University of Glasgow, may very well redefine current approaches to malaria and toxoplasmosis research in terms of treatment development. Their research which focuses on the role played by the protein AMA1 (present in both parasites) was published october 9, on the Nature Communications website. For many years AMA1 has been the focus of studies aiming to develop malaria treatments and vaccines. However, the authors of this study express their reservations about strategies that focus strictly on blocking AMA1 and show that malaria and toxoplasmosis parasites without AMA1 are still capable of developing normally.

  • Institutional | 01.10.2013

    Pr Christian Bréchot A new President for the Institut Pasteur

    Professor Christian Bréchot took office as the Institut Pasteur President on Tuesday October 1st, 2013, for a 4 years mandate. He succeeded Professor Alice Dautry.

  • Research | 01.10.2013

    Potential therapeutic targets for blocking AIDS virus replication

    Scientists from the Institut Pasteur and Inserm have identified several proteins in humans as potential new therapeutic targets for treating the AIDS virus. These proteins are part of a complex cellular mechanism that blocks the virus replication in cells called macrophages. The discovery of this mechanism and the proteins involved gives scientists a solid theoretical basis for developing new therapeutic strategies to be used alongside anti-retroviral treatments currently in use. This research was published online September 30, 2013 by the scientific journal Proceedings of the National Academy of Sciences.

  • Research | 02.08.2013

    Dengue: identifying mosquito genetic factors that control virus transmission

    Dengue is currently the most common insect-borne viral disease of humans worldwide. Scientists from the Institut Pasteur, the French National Center for Scientific Research (CNRS), and the Armed Forces Research Institute of Medical Sciences (AFRIMS) have discovered several genetic factors controlling the transmission of various dengue virus strains in a natural population of mosquitoes in Thailand. Their results indicate that the transmission of these viruses in nature depends not only on mosquito genetic factors but also on their specific interaction with viral genetic factors. This discovery significantly advances our understanding of dengue biology in nature. From a more general standpoint, this study also refines our view of the genetic basis of host-pathogen interactions. This work was published August 1st, 2013 on the PLoS Genetics website.

  • Research | 01.07.2013

    Retracing the evolutionary history and emergence of tuberculosis

    In association with CEA-Genoscope and the Sanger Institute, scientists at the Institut Pasteur in Paris, the CNRS, INSERM, the Institut Pasteur of Lille, and Université Lille 2 have recently determined the origin of the emergence of the Mycobacterium tuberculosis bacterium, the main causative agent of tuberculosis. Researchers have also provided insights into its evolutionary success. They have identified several genetic mechanisms that could have contributed to the worldwide dissemination of this pathogen, which currently infects up to 2 billion people. This research, published on the Nature Genetics website on January 6, offers possibilities for identifying new targets in the fight against tuberculosis.

  • Research | 18.06.2013

    Chikungunya : discovery of a human-specific factor involved in the virus replication

    Chikungunya : discovery of a human-specific factor involved in the virus replication

  • Research | 29.05.2013

    Worldwide Outbreak of Highly Antibiotic-Resistant Salmonella Risks Spreading to European Poultry Farms

    In a study published online May 28th for the Lancet Infectious Diseases medical journal, scientists at the Institut Pasteur in Paris and the Institut Pasteur in Morocco once again bring attention to the rapid worldwide spread of Salmonella Kentucky (S. Kentucky), a bacterium showing resistance to several classes of antibiotics. S. Kentucky is responsible for foodborne infections and has spread at an astonishing rate throughout Africa and the Middle East in the space of only a few years. In this study, the authors note that the bacterium has recently spread to India and South-East Asia and has acquired new resistance, particularly resistance to antibiotics of “last resort”. The scientists also point out the considerable risk of this multi-resistant strain spreading to farmed poultry in industrialized countries. This bacterium has already been detected in farmed turkeys in Europe.

  • Institutional | 22.04.2013

    The loss of François Jacob, a prominent name in molecular biology

    A former member of the French Second Armored Division and Companion of the Liberation, François Jacob risked his life to defend the fundamental values of democracy and freedom. He was a brilliant scientist who spent his entire career at the Institut Pasteur and who inspired many researchers who followed in his tracks. François Jacob never missed an opportunity to demonstrate his commitment to the Institut Pasteur. On November 14, 2012, alongside the President of the Republic, he was delighted to be able to inaugurate the new building that bears his name. The obituary below was written by Michel Morange, a former pupil of François Jacob who works as a biologist and science historian.

     

  • Research | 17.04.2013

    Legionellosis: unique host cell reprogramming induced by the bacterial pathogen Legionella pneumophila

    Scientists at the Institut Pasteur, the CNRS, the Institut Curie and Inserm have identified a unique mechanism that enables the bacterial pathogen Legionella pneumophila (the causative agent of Legionnaires’ disease or legionellosis) to "reprogram" the gene expression of the eukaryotic cells that it infects. This mechanism, which has never been observed before, facilitates the survival and proliferation of Legionella pneumophila during infection. The work provides precious information on the regulation of the host’s gene expression, as well as important insight into the tactics used by bacteria to manipulate host cells. This research is published online on April 17, at the Cell Host & Microbe website.
     
  • Research | 16.04.2013

    Atomic-level characterization of the effects of alcohol on a major player of the central nervous system

    Scientists at the Institut Pasteur, the CNRS and the University of Texas have been able to observe at atomic-level the effects of ethanol (the alcohol present in alcoholic beverages) on central nervous system receptors. They have identified five ethanol binding sites in a mutant of a bacterial analog of nicotinic receptors, and have determined how the binding of ethanol stimulates receptor activity. These findings can be directly extrapolated to human GABA receptors (the primary inhibitory neurotransmitters in the human brain), which are ethanol's main target in the central nervous system. This work is being published online on April 16, on the Nature Communications website. It paves the way for the synthesis of ethanol antagonist compounds that could limit the effect of alcohol on the brain.

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Pasteur museum

Welcome to Pasteur Museum


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The Pasteur Museum is located at the Institut Pasteur, situated at: 25 rue du Docteur Roux 75015 Paris, France
 

Pasteur Museum