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  • Research | 01.02.2016

    How does Legionella pneumophila, the bacterium causing legionellosis, use the host cell machinery to its own advantage?

    During analysis of its genome sequence, the team from the Biology of Intracellular Bacteria Unit (Institut Pasteur/CNRS), headed by Carmen Buchrieser, identified genes coding for proteins that were predicted to be involved in the infection of human cells. These proteins resemble proteins of higher organisms (eukaryotes), including humans, and can modify the physiology of the infected host cells. They are thus potential virulence factors. In this study, published in the journal PNAS, the researchers show that one of these proteins is secreted in the human cell and helps to block the antibacterial response of the infected cells.

  • Colonies of M. canettii and M. tuberculosis. © Roland Brosch, Institut Pasteur

    Press release | 27.01.2016

    Tuberculosis: discovery of a critical stage in the evolution of the bacillus towards pathogenicity

    It is the disappearance of a glycolipid from the bacterial cell envelope during evolution that may have considerably increased the virulence of tuberculosis bacilli in humans. Scientists have shown that this disappearance modified the surface properties of Mycobacterium tuberculosis, favoring its aggregation in "cords" and increasing its pathogenicity. These findings, which enable a better understanding of the mechanisms linked to the evolution and emergence of tuberculosis bacilli, constitute a major advance in our knowledge on this disease.

  • International News | 20.01.2016

    A new yellow fever vaccines production facility: AFD grants 6.5 million euros to the Institut Pasteur in Dakar Foundation

    In January 19, 2016 in Dakar a € 6.5 million financing agreement was signed, for the construction and equipment of an over 3000 m2 new yellow fever vaccine production facility, in the presence of His Excellency Jean-Félix- Paganon, French Ambassador to Senegal; Laurence Hart, Director of the French Development Agency (AFD) in Senegal and Professor André Spiegel, Director of the Institut Pasteur Foundation in Dakar (FIPD).

    Without treatment, vaccination is the only way to fight against yellow fever. Today, the number of produced vaccines is insufficient to meet the needs of populations in endemic countries. This project will enable the FIPD, pre-qualified by WHO for the production of this vaccine, to develop responses activities against epidemics, to monitoring surveillance of arboviruses and viral hemorrhagic fever and to intensify training.

  • Dannemann et al./American Journal of Human Genetics 2016

    Press release | 08.01.2016

    Neanderthal genes gave modern humans an immunity boost, allergies

    When modern humans met Neanderthals in Europe and the two species began interbreeding many thousands of years ago, the exchange left humans with gene variations that have increased the ability of those who carry them to ward off infection. This inheritance from Neanderthals may have also left some people more prone to allergies. The discoveries add to evidence for an important role for interspecies relations in human evolution and specifically in the evolution of the innate immune system, which serves as the body's first line of defense against infection.

  • Aedes aegypti mosquito. © Institut Pasteur

    Press release | 08.01.2016

    The Institut Pasteur in French Guiana publishes the first complete genome sequence of the Zika virus circulating in the Americas

    Having confirmed the first cases of infection in Suriname then in French Guiana, the Institut Pasteur in French Guiana has sequenced the complete genome of the Zika virus, which is responsible for an unprecedented epidemic currently sweeping through the tropical regions of the Americas. Published in The Lancet medical journal today, the analysis of this sequence shows almost complete homology with the strains responsible for the epidemic that occurred in the Pacific in 2013 and 2014.

  • Jacques Ravel. Institut Pasteur

    Press release | 07.01.2016

    University of Maryland School of Medicine researcher Jacques Ravel receives prestigious international science award

    Jacques Ravel, PhD, Professor of Microbiology and Immunology, as well as Associate Director for Genomics at the Institute for Genome Sciences (IGS), both at the University of Maryland School of Medicine, has been named a 2015-2017 Blaise Pascal International Research Chair, one of the most prestigious European science awards. He is spending this year working at the Institut Pasteur in Paris, and over the next two years will divide his time between Paris and Baltimore. He focuses on the human microbiome and its role in women’s health.

  • International News | 30.12.2015

    The Institut Pasteur in Bangui confirms cases of monkeypox virus infection in Central African Republic

    The Institut Pasteur in Bangui confirmed cases of monkeypox virus infection in Bangassou about 800 km from Bangui capital city of the Central African Republic.

    A team from Doctors without Borders Belgium located in this area at the border of the Democratic Republic of the Congo, has collected samples from two children of the same family who presented with rashes (maculopapular) after consuming thryonomys meat a rodent locally known as sibissi.

    One of the children, aged 9 years died. As the clinical picture was not in favor of a measles infections, highly endemic in Central African Republic, the samples were sent to the Institut Pasteur in Bangui for analysis.

  • Activation of the inflammasome. The mechanism of an AIDS vaccine candidate filmed in vivo. © Institut Pasteur

    Press release | 21.12.2015

    The mechanism of an AIDS vaccine candidate filmed in vivo

    Using innovative technology, scientists from the Institut Pasteur and Inserm have filmed in vivo the process by which an AIDS vaccine candidate, developed by the French Vaccine Research Institute and the ANRS, triggers the immune response. This previously unseen footage clearly shows how the vaccine recruits the immune cells needed to destroy infected cells. These results shed new light on the mode of action and potential of this vaccine.

  • The Institut Pasteur in French Guiana detects the first case of Zika virus in French Guiana.

    International News | 18.12.2015

    The Institut Pasteur in French Guiana detects the first case of Zika virus in French Guiana.

    The virology laboratory of the Institut Pasteur in French Guiana (National Reference Centre for arboviruses, associated laboratory for the Antilles and French Guiana) has just confirmed the first case of Zika virus in Guiana. To date, no local transmission has been identified. This case was imported from the neighboring Surinam where the Institut Pasteur in French Guiana virology laboratory already confirmed last month the first case of Zika virus infection .

     

  • Muscle tissue after sepsis. Sepsis: cell therapy to repair muscle long-term impairment. © Institut Pasteur

    Press release | 15.12.2015

    Sepsis: cell therapy to repair muscle long-term impairment

    Scientists have recently published a paper in which they reveal mayor players in the severe muscle damage caused by sepsis, or septicemia, which explains why many patients suffer debilitating muscle impairment long-term after recovery. They propose a therapeutic approach based on mesenchymal stem cell transplantation, which has produced encouraging results and has proved successful in restoring muscle capacity in animals.

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Welcome to Pasteur Museum


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The Pasteur Museum is located at the Institut Pasteur, situated at: 25 rue du Docteur Roux 75015 Paris, France
 

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