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  • The Ebola virus adapted to better infect humans during the 2013-2016 epidemic

    Research | 07.11.2016

    The Ebola virus adapted to better infect humans during the 2013-2016 epidemic

    An international coalition of scientists* involving teams from the Institut Pasteur, has revealed that adaptive mutations to the Ebola virus occurred during the epidemic that swept across West Africa from 2013 onwards. In what remains the most devastating outbreak of this disease ever recorded, it was already known that several strains of the virus circulated at the same time. This new functional study demonstrates that some variants of the virus actually increased their ability to infect humans – to the detriment of their infectivity in bats.

  • Press release | 04.11.2016

    Malaria – Discovery of a molecular marker associated with piperaquine resistance in parasites

    Scientists have identified a molecular marker able to detect Plasmodium falciparum malaria parasites resistant to piperaquine, a drug currently used in combination with artemisinin derivatives in the latest generation of antimalarial treatments recommended by the WHO. This discovery should pave the way for rapid monitoring strategies and enable public health policy makers to recommend effective antimalarial treatments adapted to the local epidemiological situation.

  • The specific VHH antibody for plaques. © Institut Pasteur

    Press release | 03.11.2016

    Diagnosis of Alzheimer's disease: llama antibodies detect cerebral lesions

    The major challenge facing physicians treating Alzheimer's is the ability to detect markers of the disease as early as possible. These markers, located in the brain, are difficult to access, hampering diagnosis. Using two types of llama antibody capable of crossing the blood-brain barrier, scientists have developed a non-invasive approach to reach brain cells in a mouse model of the disease. Once in the brain, these llama antibodies can specifically mark and show amyloid plaques and neurofibrillary tangles, the two types of lesions that characterize Alzheimer's disease.

  • Illustration © Jérome Bon

    Press release | 21.10.2016

    Africans and Europeans have genetically different immune systems... and Neanderthals had something to do with it

    In a large-scale study, scientists from the Institut Pasteur and the CNRS unraveled the immune responses of 200 African and European individuals. They show that there is indeed a difference in the way these populations respond to infection, that this response is largely controlled by genetics, and that natural selection has played an important role in shaping such immune profiles.

  • Table salt to diagnose malaria, at the Centre Pasteur in Cameroon

    International News | 20.10.2016

    Table salt to diagnose malaria

    At the Centre Pasteur in Cameroon, the International Four Year Group (G4) on malaria created in 2013 is developping a diagnostic test working with common table salt. Dr. Lawrence Ayong, head of the group explains how this innovative tool works as well as his ambitious research program on malaria.

  • Efficacy of cancer treatment

    Research | 18.10.2016

    Efficacy of cancer treatment: two bacteria in the microbiota identified

    Scientists from the Institut Pasteur, in collaboration with the Institut Gustave-Roussy, have identified two bacterial species naturally present in the body, Enterococcus hirae and Barnesiella intestinihominis, which enhance the effect of cyclophosphamide, a common chemotherapy treatment. The scientists had already proven the role of the microbiota in the efficacy of chemotherapy. This time, they characterized two bacteria responsible for this action.

     

  • Esrrb transcription factor plays a key role in maintaining stem cell identity even after countless divisions

    Research | 17.10.2016

    Esrrb transcription factor plays a key role in maintaining stem cell identity even after countless divisions

    How is it that embryonic stem cells are able to divide over and over again without ever losing their identity? Scientists from the Institut Pasteur have recently answered this question with their discovery that a transcription factor, Esrrb, is directly involved in controlling the transfer of information that enables stem cells to continue expressing the same genes as the initial stem cell even after several generations of division. This epigenetic mechanism sheds light on the way in which cell identity is passed on. More broadly, the newly discovered mechanism could explain the self-renewal of cancer stem cells and provide new avenues for research into preventing their proliferation. In the longer term, understanding how stem cells work could give scientists in the field of regenerative medicine a high degree of precision in guiding the multiplication of these cells with a view to producing tissues or even organs.

  • Press release | 12.10.2016

    Press release following publication of an article in The Korea Times on October 5, 2016

    In an article published online in The Korea Times on October 5, 2016, serious accusations were made against the Institut Pasteur in Korea and the Institut Pasteur in Paris and its President.

  • Tissue infected by Listeria monocytogenes (bacteria are shown in red). ©Institut Pasteur

    Research | 10.10.2016

    How investigating the population biology of Listeria is ushering in a new era in listeriosis surveillance

    By investigating the genome sequence of an international collection of strains of Listeria monocytogenes bacteria, two Institut Pasteur scientists, Sylvain Brisse and Marc Lecuit, have helped improve our understanding of how different Listeria strains circulate across the world. Their method of typing strains using high-throughput sequencing signals a new era for the global monitoring of listeriosis cases, paving the way for faster, more precise and internationally reproducible comparative analysis of strains. The Institut Pasteur's collaboration with prestigious health research institutes* from the United States, the United Kingdom, Canada, Denmark and France for this study indicates the importance of these findings, which mark a turning point in the field.

     

  • Bacteriophages eliminating Staphylococcus aureus bacteria on a petri dish. Identification of a new bacterial defense system against phages. © Institut Pasteur.

    Research | 23.09.2016

    Identification of a new bacterial defense system against phages

    Bacteria are under constant attack from viruses known as bacteriophages or phages, recognized as the most abundant organisms on the planet. In response, bacteria have developed an entire arsenal of defense mechanisms against phages, including CRISPR systems, the recent discovery of which is currently giving rise to a surge of new applications, especially in the field of gene editing (gene therapy). Scientists have recently identified a new system used by staphylococci to defend themselves against phages.

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The Pasteur Museum is located at the Institut Pasteur, situated at: 25 rue du Docteur Roux 75015 Paris, France
 

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