Bacterial genomes generally contain a single chromosome and one or more extrachromosal elements such as plasmids. The initiation of bacterial chromosome replication must be carefully checked to ensure that chromosome duplication occurs only once per cell cycle. The bacterial pathogen responsible for cholera epidemics, Vibrio cholerae, is distinctive in that it has two chromosomes. The researchers have revealed an original, energy-saving mechanism known as the "replication checkpoint" that coordinates replication of the two chromosomes with the V. cholerae cell cycle.
- Institut Pasteur
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