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  • SFB attached directly to the intestinal epithelial cells. Segmented filamentous bacteria, partners in intestinal immunity, finally cultured in vitro. © Institut Pasteur and Institut Imagine

    Research | 19.01.2015

    Segmented filamentous bacteria, partners in intestinal immunity, finally cultured in vitro

    Despite the vital role of segmented filamentous bacteria in establishing gut immune homeostasis in vivo in mice, scientists, for the past 50 years, have been unable to reproduce this symbiosis in vitro to shed light on the cellular and molecular interactions involved. Now, scientists have successfully cultured and reproduced the complex life-cycle of these bacteria outside their host for the first time.

  • Hepatic macrophage (in green) ingesting by phagocytosis pathogenic bacterium Listeria monocytogenes (in red). © Institut Pasteur

    Research | 09.01.2015

    Resident and recruited macrophages orchestrate the liver's defense against infection

    Scientists have demonstrated that liver-resident macrophages are rapidly killed by the pathogenic bacterium Listeria monocytogenes. This early death triggers the recruitment of macrophages from the bloodstream to the liver. These macrophages start by bringing the bacterial infection under control; then, in an unexpected development, they actually replace the liver-resident macrophages that have been killed by the infection.

  • A lymphocyte infected by HIV and transmission of the virus to neighboring cells © Institut Pasteur

    Research | 27.11.2014

    Defense mechanism against HIV-1 revealed

    Scientists have discovered how some of these restriction factors inhibit HIV replication in lymphocytes. These proteins belong to the IFITM (interferon-induced transmembrane proteins) family; they are broad-spectrum antiviral proteins that act on a wide range of viruses including influenza, dengue, etc. Little was previously known about their effect on HIV-1.

  • intestinal immunity, © Institut Pasteur

    Research | 07.11.2014

    A better understanding of the intestinal immunity

    The innate lymphoid cells contribute to immune defense by maintaining the integrity of the intestinal barrier. ILC are made in the bone marrow but must find their way to the gut mucosa where they perform their function. Scientists have discovered how this migration process is regulated.

  • Virus Ebola, Blood Ebola survivors tested as short-term treatment option, Institut Pasteur

    Research | 23.10.2014

    Blood Ebola survivors tested as short-term treatment option

    An international research consortium will assess whether treatment with antibodies in the blood of Ebola survivors could help infected patients to fight off the disease. If proven effective, this straightforward intervention could be scaled up in the short term and provide an urgently needed treatment option for patients in West Africa.

  • A new mechanism of gene regulation in Listeria, Listeria invading an epithelial cell, © Institut Pasteur

    Research | 22.08.2014

    A new mechanism of gene regulation in Listeria

    How do bacteria perceive their environment? How do they find and detect nutrients? How do they eat? In an article published in the journal Science, researchers reveal a new system of gene regulation in Listeria monocytogenes, the bacteria in food and responsible for listeriosis.

  • Section of Mycobacterium bovis © Institut Pasteur/Antoinette Ryter

    Research | 22.07.2014

    TB transmission: Why tubercle bacilli of animal origin don't spread within human populations

    Researchers examined the mechanisms involved in tuberculosis (TB) transmission to explain why tubercle bacilli of animal origin don't spread within human populations. Their work opens up new possibilities for understanding the functions and mechanisms involved in TB transmission in humans and could eventually lead to therapeutic solutions for preventing the spread of this infectious agent.

     

  • Well of Banizoumbou village, Niger, Assessing the effectiveness of anti-malaria campaigns, © Institut Pasteur

    Research | 01.07.2014

    Assessing the effectiveness of anti-malaria campaigns

    The fight against malaria has been declared a Millennium Development Goal by the World Health Organization, and as such receives significant worldwide funding. Despite this fact, the public health agencies that manage this program lack the means to assess whether campaigns are effectively able to reduce or eliminate malaria within individual countries.

  • Research | 29.06.2014

    EBOLA: Institut Pasteur in the front line against Ebola outbreak

     

    An international team of scientists from Institut Pasteur Paris and Dakar are on the front of the outbreak in Guinea. 

     

    The Institut Pasteur confirmed the outbreak on March 21, 2014. Since the outbreak is still continuing, scientists and materials have been sent from Institut Pasteur Paris and Dakar to Guinea. 

    Experts from Institut Pasteur Dakar are investigating new cases in Conackry. Scientists from the Emerging viral infection unit (UBIVE) have supported the European Mobile Lab (EMLab) in Gueckedou (Guinea). 
     
    The Institut Pasteur will attend the international emergency meeting organized in Ghana by WHO 2&3 July to reinforce the international response to the spread of the disease.

    This meeting will be attended by Health Ministers from 11 countries - Guinea, Liberia, Sierra Leone, Côte d'Ivoire, Democratic Republic of Congo, Gambia, Ghana, Guinea-Bissau, Mali, Senegal and Uganda - and different partners of the organization involved in the response to the outbreak of Ebola including representatives from MSF, Institut Pasteur and the European Union.

     

  • Scientists discover a novel mechanism in the development of pre-eclampsia © Institut Pasteur

    Research | 23.06.2014

    Scientists discover a novel mechanism in the development of pre-eclampsia

    No treatment currently exists for pre-eclampsia, a gestational disorder which affects over 8 million pregnant women worldwide and can cause premature delivery or death of the mother or the fetus.

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The Pasteur Museum is located at the Institut Pasteur, situated at: 25 rue du Docteur Roux 75015 Paris, France
 

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