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  • Papillomavirus,  Human papillomavirus linked to auto-immune disease, © Institut Pasteur

    Press release | 14.10.2014

    Human papillomavirus linked to auto-immune disease

    Erosive oral lichen planus (OLP) is an auto-immune disease affecting skin and mucous membranes which results in an abnormal immune response against mucocutaneous cells. Today, scientists have proven that the immune cells involved in OLP are the same as those activated during an immune response to human papillomavirus (type HPV-16). This suggests a link between OLP and HPV.

  • Pseudomonas aeruginosa,  © Institut Pasteur

    Press release | 07.10.2014

    Cystic fibrosis: how a bacterium manipulates its host to eradicate an opponent

    The main cause of death in patients suffering from cystic fibrosis is respiratory infection caused by different bacterial populations, which vary according to the age of the patient. Scientists at the Institut Pasteur and Inserm have identified a novel mechanism used by the Pseudomonas aeruginosa bacterium to hijack the immune system of its host in order to eradicate another bacterium, Staphylococcus aureus ("golden staph"), and take its place in airways.

  • The three-dimensional structure of SUB1, Highly regulated therapeutic target shows promise in the search for new antimalarial treatments, © Jean-Christophe Barale, Institut Pasteur

    Press release | 10.09.2014

    Highly regulated therapeutic target shows promise in the search for new antimalarial treatments

    Artemisinin is currently the most effective malarial treatment available. However, the recent emergence in South-East Asia of artemisinin-resistant parasites strengthens the urgent need to identify a new generation of antimalarial drugs. In this context, scientists have determined the three-dimensional structure of a promising new therapeutic target for malaria: SUB1.

  • A neuron seen under fluorescence microscopy, Autism: SHANK gene may indicate the severity of the disorder, © Institut Pasteur

    Press release | 04.09.2014

    Autism: SHANK gene may indicate the severity of the disorder

    Thanks to a large-scale study conducted on nearly 1,000 autistic patients, scientists succeeded in mapping the clinical incidence and impact of certain genetic mutations linked to the cognitive and intellectual abilities of the patients. Mutations affecting the SHANK3 gene were shown to coincide with the most severe cases of autism and are associated with 1 out of 50 children with autism and intellectual deficits.

  • Neo-neurons in an adult brain, Pierre-Marie Lledo, Mental states control the integration of new neurons in the adult brain, © Institut Pasteur

    Press release | 02.09.2014

    Mental states control the integration of new neurons in the adult brain

    Although it has been known for several years that the adult brain is capable of producing new neurons, how these neurons are integrated into existing, functional nerve circuits has hitherto remained a mystery. Scientists have just shown that new neurons set up a denser network of connections with the rest of the brain in contexts of active (as opposed to passive) motivation and learning.

  • Ebola virus, The Institut Pasteur steps up its action against Ebola, © Institut Pasteur

    Press release | 01.09.2014

    The Institut Pasteur steps up its action against Ebola

    Ever since the Ebola virus was identified in Guinea in March 2014, the designated WHO Collaborating Centers within the Institut Pasteur and Institut Pasteur International Network have been assisting the international aid initiative via diagnostic support and epidemiological surveillance. Now, faced with the seriousness and spread of the epidemic, the Institut Pasteur and Institut Pasteur International Network are strengthening and coordinating their efforts in order to effectively fight the disease.

  • Potential strategies for limiting the hepatitis C epidemic in Egypt

    Press release | 28.08.2014

    Potential strategies for limiting the hepatitis C epidemic in Egypt

    In the fight against hepatitis C, directing preventive and curative interventions towards sufferers of chronic diseases requiring regular medical care would be an effective means of reducing transmission of the hepatitis C virus (HCV) in Egypt, and undoubtedly also in other countries with limited resources. This theory has arisen from a mathematical modeling study carried out as part of the ANRS 1211 study, conducted jointly by scientists at the Institut Pasteur, the CNAM and their fellow scientists in Egypt.

  • Streptococcus agalactiae in white blood cells (polynuclear neutrophils) in the cerebrospinal fluid of a child with meningitis (optical microscopy, Gram stain). © Claire Poyart, CNR-Strep (AP-HP, Inserm)

    Press release | 04.08.2014

    The emergence of neonatal group B streptococcal infections explained

    Scientists from the Institut Pasteur and the CNRS have recently revealed the cause behind the emergence in the 1960s of neonatal infections due to group B streptococcus. These findings prove that the sudden emergence of infections caused by this bacterium resulted from the widespread use of an antibiotic, tetracycline, from the 1950s onwards.

  • Can injuries to the skin be painless? National Buruli ulcer control Programme, Benin ©OMS

    Press release | 19.06.2014

    Can injuries to the skin be painless?

    When the body receives an injury to the skin, a signal is sent to the brain, which generates a sensation of pain. Researchers have studied lesions in patients with Buruli ulcer, a tropical disease. They show that, despite the extent and severity of these wounds, they are less painful than others that seem relatively minor (e.g. scratches, low-degree burns). They discovered an analgesic mechanism that limits the transmission of pain signals to the brain. An understanding of this mechanism may be useful in developing new drugs for pain relief.

     

  • Hair bundles of the auditory outer hair cells - Mild hearing impairment may indicate greater underlying problems - © Institut Pasteur

    Press release | 12.06.2014

    Mild hearing impairment may indicate greater underlying problems

    Scientists identified mice models that mimic high-frequency hearing impairment in humans. Their work sheds light on the anomalies causing the hearing impairment and could explain the pronounced masking effect experienced by some hearing-impaired individuals when trying to discriminate high-frequency sounds in noisy environments. The scientists suggest that more substantial auditory assessments would enable clinicians to improve diagnosis of these auditory impairments.

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The Pasteur Museum is located at the Institut Pasteur, situated at: 25 rue du Docteur Roux 75015 Paris, France
 

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