The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Whooping cough: increase in vaccine coverage, decrease in bacterial virulence
The whooping cough monitoring carried out in France has enabled Institut Pasteur and CNRS researchers to analyze Bordetella pertussis, the bacterium responsible for whooping cough. For the first time, among the strains in circulation, they have identified bacteria not expressing some of the virulence factors targeted by the vaccine, such as the bacterial toxin. These observations confirm the success of the vaccination campaigns carried out in France since the 1960s.
Paris, august 25, 2009
Photo du bacille de Bordet GengouBy comparing the bacteria circulating in different world regions, some of which had carried out mass vaccination against whooping cough in children, the Molecular Prevention and Therapy of Human Diseases team (Institut Pasteur/URA CNRS 3012) was able to demonstrate last year that vaccination against whooping cough enabled strains similar to those in the first-generation vaccine to be controlled, but that others were still in circulation.
The researchers also observed that the increase of certain sequences in the bacterial genome could enable the gradual elimination of the genes encoding the virulence factors.
The scientists have now been able to confirm their theory through the genetic analysis of isolates collected in France. Their work shows the emergence for the first time, in France, in 2007 of Bordetella pertussis strains not expressing some of the bacterium’s virulence factors, such as its toxin because of the total elimination or inactivation in the bacterial genome of the genes encoding these factors.
These observations support the French policy of vaccination against whooping cough pursued since 1960, with a new vaccine that specifically targets bacterial virulence factors being introduced for children and teenagers in 1998 and for adults in 2004. High vaccine coverage will undoubtedly be able to speed up control of whooping cough.