The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Whooping cough: bacterial monitoring for better prevention
Researchers from the Institut Pasteur in Paris and the Institut Pasteur in Lille have analyzed the consequences of intensive vaccination of young children against whooping cough on the bacterium agent of the disease. Their observations highlight the importance of continuing bacterial evolution in order to adapt vaccine strategies.
Paris, july 8, 2008
consequences of intensive vaccination of young children against whooping cough on the genome of Bordetella pertussis – the bacterium agent of the disease.
Extensive genome analysis was conducted on clinical isolates collected on four continents, in areas where vaccine coverage of young children is high
The results show that the bacteria targeted by the vaccine have been controlled by widespread child vaccination. This observation confirms the success of vaccine campaigns conducted in these countries, and particularly in France, since the 1960s.
Analysis of bacterial genomes shows that current cases of whooping cough are caused by B. pertussis strains that are different from the vaccine strains. Researchers have therefore underlined the importance of adapting vaccine strategies, as recommended by the French health authorities, by using new vaccines for adolescents and adults that no longer target specific bacteria but the virulence factors of circulating bacteria. This type of vaccine has been used in France since 1998.
Scientists have finally observed that some bacterial genetic sequences likely to be involved in bacterial virulence are particularly unstable. They could therefore be gradually eliminated from the bacterial genome. High vaccine coverage, based on these new vaccines which target virulence, could therefore speed up control of whooping cough. Monitoring of the disease in children, adults and senior citizens will enable this scenario to be confirmed.
« Genomic Content of Bordetella pertussis Clinical Isolates Circulating in Areas of Intensive Children Vaccination », PloS One, June 18, 2008.
(1) Institut Pasteur, Molecular Prevention and Therapy of Human Diseases Unit, URA-CNRS 3012, Paris, France
(2) Institut Pasteur in Lille, Transcriptome and Genome Applied Studies Laboratory – Lille Microarray Facility, UMR 8161-IFR 142, Lille, France
(3) Institut Pasteur, Public Health Platform, Paris, France