The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Nicotine: a receptor from the past helping to develop drugs of the future
Researchers at the Institut Pasteur and CNRS have just determined the structure of a bacterial protein similar to the human nicotine receptor, and have published this result in the journal Nature. This is an important step for the molecular modeling of substances able to interact with this receptor and which could help treatment of nicotine addiction.
Nicotine is the principal substance in tobacco causing addiction, particularly in terms of the impairment it causes to the reward system, which is the natural management system of our desires, pleasures and emotions. At this level, it acts by interacting with receptors known as nicotinic.
Paris, november 5, 2008
Two groups of researchers at the Institut Pasteur, the Channel-Receptors 5-year group (1) , led by Pierre-Jean Corringer, CNRS Research Manager, and the Structural Dynamics of Macromolecules Unit (2) , led by Marc Delarue, also CNRS Research Manager, have determined the atomic structure (in 3D) of a nicotinic receptor homolog from a bacterium.
“This bacterial homolog has been discovered by comparative genomics. It is derived from a common ancestor dating back between one and three billion years,” explained Pierre-Jean Corringer. “Faced with the difficulty of obtaining a 3D structure of the human nicotinic receptor, we chose to establish a 3D structure of this bacterial protein, which does not have exactly the same function, but is similar to the human molecule from a purely structural point of view.”
The 3D structure of another bacterial homolog of the human nicotinic receptor had already been obtained at the beginning of 2008 by a different team, but this was a structure in the “inactive” state, whereas the Pasteur teams established the structure of the protein in an “active” state, in other words a true physiological state. In this way they were able to compare the two structures in order to understand how these receptors are activated by pharmaceutical compounds.
This will enable researchers to draw closer to the 3D structure of the human nicotinic receptor and also to advance in the field of molecular modeling, or drug design: it is a matter of finding molecules able to interact with the nicotinic receptor, in other words candidate nicotine withdrawal drugs.
We should not forget that, according to the World Health Organization, tobacco is the second cause of mortality throughout the world, and is currently responsible for one in six adult deaths.
In addition, the bacterial receptors studied by researchers are also homologous to other human receptors, in particular GABAA receptors, which are the targets of general anesthetics and anxiolitics. The 3D structure obtained by the work of researchers at the Institut Pasteur could therefore have an impact on the design of these compounds.
1. URA CNRS 2182
2. URA CNRS 2185
“X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation”: Nature, advanced publication online, November 5th, 2008
Nicolas Bocquet (1)*, Hugues Nury (1,2)*, Marc Baaden (4), Chantal Le Poupon (1), Jean-Pierre Changeux (3), Marc Delarue (2) & Pierre-Jean Corringer (1)
1. Institut Pasteur, Channel-Receptors 5-year group, CNRS URA 2182, Paris
2. Institut Pasteur, Structural Dynamics of Macromolecules Unit, CNRS URA 2185, Paris
3. Institut Pasteur, CNRS URA 2182, F75015, Paris
4. Institute of Physical Chemical Biology, CNRS UPR 9080, Paris, France.