The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Malaria Takes a Hit – Two New Molecules Stop P. falciparum in its Tracks
Researchers at the Institut Pasteur and the French National Center for Scientific Research (CNRS), in collaboration with Imperial College London, have synthesized two molecules capable of quickly and irreversibly stopping the growth of P. falciparum at every blood stage of its life cycle. These molecules work by inhibiting the histone methyltransferase enzymes necessary for the parasite’s development. This research was published on September 24, 2012 in the journal PNAS and was recently presented at the 23rd Annual Molecular Parasitology Meeting in Woods Hole, Massachusetts (USA).
Paris, September 27, 2012
According to WHO estimates, malaria causes between 1 and 3 million deaths each year. Disadvantaged, tropical regions in Africa, Asia, and Latin America are the most affected by the disease. Although there is no malaria vaccine, several antimalarial molecules are currently used for preventive and therapeutic purposes. However, the growing resistance observed in recent years has made it necessary to find new therapeutic targets and develop inhibitory molecules.
Artur Scherf, head of the Institut Pasteur Biology of Host-Parasite Interactions Unit (CNRS Associated Research Unit 2581), led the researchers, who, after identifying two molecules (BIX-01294 and TM2-115), successfully tested them in vitro on P. falciparum and in vivo on P. berghei (the parasite responsible for malaria in rodents).
The results of this research are significant. When introduced to a culture of P. falciparum both BIX-01294 and TM2-115 rapidly trigger the irreversible death of the parasite. After only 12 hours of incubation with BIX-01294 all P. falciparum parasites in culture were killed. Researchers obtained similar results from in vivo testing in mice models, which showed a clear decrease in the presence of P. berghei after the administration of TM2-115.
BIX-01294 and TM2-115 have similar modes-of-action in that they both significantly reduce a form of histone H3 (H3K4me3) involved in the regulation of gene expression for P. falciparum and P. berghei. This research therefore suggests that histone H3, and histone methyltransferases in general, constitute a new class of therapeutic target in the development of effective treatment for malaria. Researchers also emphasize the potential of the BIX-01294 inhibitor to be effective at every stage of the life cycle of P. falciparum as well as the other species of the plasmodium genus that infect humans.
This research was supported by the New York Pasteur Foundation and the Bill and Melinda Gates Foundation and received funding from the European Research Council.
Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity aginst all blood stage forms in Plasmodium falciparum, Proceedings of the National Academy of Sciences, september 24, 2012.
Nicholas A. Malmquist (1,2), Thomas A. Moss (3), Salah Mecheri (1,2), Artur Scherf (1,2), Matthew J. Fuchter (3)
(1) Unité de Biologie des interactions Hote-Parasite, Institut Pasteur, France
(2) Unité de Recherche Associée 2581, Centre National de la Recherche Scientifique, France
(3) Department of Chemistry, Imperial College, Royaume-Uni