The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Malaria could increase mother-to-child transmission of HIV
Researchers from the Institut Pasteur have published a study in the journal AIDS that demonstrates how infection in a pregnant woman by the malaria parasite could increase the risk of in utero transmission of the AIDS virus to the child. This study reinforces epidemiological observations and emphasises the importance of treating malaria in HIV-positive women.
Paris, march 18, 2008
Several epidemiological studies have revealed correlations between malarial infections in pregnant women who are also infected by HIV and an increase in the mother-to-child transmission of the virus. However, the mechanisms of this phenomenon remained unknown.
Earlier studies, supported in part by the ANRS, led the researchers to propose that sequestration of the Plasmodium falciparum parasite in the placenta of the pregnant woman might cause this increase. Their hypothesis was that binding of the malaria parasite to placental cells locally stimulated the replication of HIV-1, thereby increasing mother-to-child transmission of the virus in utero.
The study, conducted by researchers from the Regulation of Retroviral Infections Unit, in collaboration with two other teams from the Institut Pasteur in Paris and the Virology Laboratory at the Pasteur Centre of Cameroon in Yaoundé, set out to examine this hypothesis.
The researchers worked with an experimental placental cell line in culture, which was placed in contact with a protein molecule used by the parasite to bind to the surface of the placental cells. The researchers thereby showed that the replication rates of HIV-1 strongly increased according to the amount of the parasite molecule added.
“Our study suggests that specific interactions between the malaria parasite and the placenta contribute to mother-to-child transmission of the AIDS virus in areas where the two diseases co-localize.”, the authors concluded. “Improved implementation of anti-malaria therapy in addition to antiretroviral therapies throughout pregnancy may help to prevent mother-to-child transmission of HIV-1”.
"Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium falciparum": AIDS, March 18, 2008.
Ahidjo Ayouba (1), Cyril Badaut (2), Anfumbom Kfutwah (3), Claude Cannou (1), Alexandre Juillerat (2), Stéphane Gangnard (2), Charlotte Behr (4), Odile Mercereau-Puijalon (4), Graham A. Bentley (2), Françoise Barré-Sinoussi (1), Elisabeth Menu (1)
1. Regulation of Retroviral Infections Unit , Institut Pasteur, Paris
2. Structural Immunology Unit (CNRS URA 2185), Institut Pasteur, Paris
3. Virology Laboratory, Pasteur Centre of Cameroon, Yaoundé
4. Parasite Molecular Immunology Unit (CNRS URA 2581), Institut Pasteur, Paris