The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
A major discovery in the fight against streptococcal infections
Group B streptococcus, or Streptococcus agalactiae, is responsible for infections of the bovine mammary gland (mastitis), and can also cause serious diseases in humans (e.g. pneumonia, meningitis, septicemia), particularly in neonates. Researchers at INRA and the Institut Pasteur demonstrated the key role played by a molecule known as antigen B, located on the surface of the bacterium. Their research has determined this molecule’s involvement in controlling bacterial growth, and provides a promising outlook for the fight against these infections. The findings were published today (June 14, 2012) in PLoS Pathogens.
Paris, june 14, 2012
Discovery of the function of antigen B, which is essential for normal bacterial development
In 1934, the American bacteriologist, Rebecca Lancefield, developed an immunological technique for identifying streptococci, based on the presence of a complex sugar, or polysaccharide, in the bacterial cell wall. In Streptococcus agalactiae, this polysaccharide, known as antigen B, had no known biological function.
Researchers from the INRA center in Jouy-en-Josas and the Institut Pasteur have now demonstrated the major biological role played by this molecule exposed on the bacterial surface and universally used in clinical bacteriology identification tests since its discovery nearly 80 years ago.
The wall is an integral component of the bacterial cell; reactions take place here that control cell growth and division, which are the target of many antibiotics. These highly complex phenomena involve multiple molecular interactions, which require a high level of coordination in terms of location and activity. The researchers showed that antigen B is essential for the correct progress of bacterial cell growth, division and morphogenesis. The photographs below illustrate the cell defects observed in the absence of antigen B.
The outlook in the fight against streptococcal infections
Surface polysaccharides similar to antigen B are present on the surface of many of the streptococci that cause a range of human and animal infections. The synthesis of surface polysaccharides therefore offers a potential target for the development of new, anti-infective molecules.