The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Legionellosis: unique host cell reprogramming induced by the bacterial pathogen Legionella pneumophila
Scientists at the Institut Pasteur, the CNRS, the Institut Curie and Inserm have identified a unique mechanism that enables the bacterial pathogen Legionella pneumophila (the causative agent of Legionnaires’ disease or legionellosis) to "reprogram" the gene expression of the eukaryotic cells that it infects. This mechanism, which has never been observed before, facilitates the survival and proliferation of Legionella pneumophila during infection. The work provides precious information on the regulation of the host’s gene expression, as well as important insight into the tactics used by bacteria to manipulate host cells. This research is published online on April 17, at the Cell Host & Microbe website.
Paris, April 17, 2013
Intracellular pathogens adopt various strategies to circumvent immune defenses and proliferate intracellularly. Some are able to modulate the gene expression of the host cell to their own advantage. One of the ways they manage this is by initiating epigenetic modifications (in other words altering not the genes themselves, but their environment). This is the case for Legionella pneumophila, a bacterial pathogen that causes Legionellosis - a disease characterized by an acute pulmonary infection, which is often fatal when not treated promptly.
The teams of Carmen Buchrieser, head of the unit Biology of the Intracellular Bacteria at the Institut Pasteur and associated to CNRS, and Raphaël Margueron, of the Genetics and Developmental Biology Unit (CNRS/Institut Curie/Inserm/Pierre and Marie Curie University), at the Institut Curie, have discovered a previously unknown epigenetic mechanism that enables Legionella pneumophila to alter the gene expression of host cells in order to promote its own development. The scientists are putting forward the theory that there are expression changes in a total of 4,870 host genes. Some of these genes, such as those coding for interleukin 6 or the TLR5 receptor, are directly involved in the innate immune response of the host cell to the infection.
The following mechanism is used by Legionella pneumophila: the bacterium secretes an enzyme called RomA, that modifies the structure and conformation of the host cell's DNA, and this restricts access to many genes. Consequently, the expression of these genes is markedly reduced.
This work sheds new light on the regulation of eukaryotic gene expression (eukaryotes are cells with a nucleus), and therefore on the functioning of eukaryotic cells in general. It also provides information on the strategies employed by intracellular pathogens for survival and development during infection.
Illustration - Copyright Institut Pasteur
Caption - Legionella pneumophila, the bacterium responsible for severe acute lung disease.
Legionella pneumophila Effector RomA Uniquely Modifies Host Chromatin to Repress Gene Expression and Promote Intracellular Bacterial Replication, Cell Host & Microbe, April 17, 2013.
Monica Rolando (1,2), Serena Sanulli (3,4,5), Christophe Rusniok (1,2), Laura Gomez-Valero (1,2), Clement Bertholet (3,4,5), Tobias Sahr (1,2), Raphael Margueron (3,4,5) and Carmen Buchrieser (1,2)
(1) Institut Pasteur, Biology of Intracellular Bacteria,
(2) CNRS UMR 3525, Paris, France,
(3) Institut Curie, Genetics and Developmental Biology Unit,
(4) CNRS UMR 3215,
(5) INSERM U934, Paris, France.