The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Discovery of a new group of highly susceptible malaria mosquitoes in Africa
In the course of a large genetic study of malaria vector mosquitoes in Burkina Faso, West Africa, researchers at the Institut Pasteur, the French National Center for Scientific Research (CNRS) and their collaborators have discovered a new subspecies of the mosquito Anopheles gambiae, the world’s most important malaria vector. This new mosquito group, which may be an especially efficient malaria vector, was identified using a novel sampling method that for the first time accounted for mosquito behavior. The results of this study, published in the journal Science, highlight the importance of including mosquito behavior as a factor in malaria vector control strategies. A better accounting of mosquito behavior could expand the reach of control measures to target all malaria vector populations, and not just those found indoors.
Paris, febuary 4, 2011
To date, most field studies of malaria transmission by the mosquito Anopheles gambiae have been based on the assumption that people are mainly bitten inside their houses during the night. As a consequence, researchers investigating and measuring malaria transmission have collected mosquitoes primarily inside of houses.
Researchers of the Unit of Genetics and Genomics of Insect Vectors (Institut Pasteur / CNRS URA 3012), along with collaborators from the Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso, the University of Minnesota (USA), and Harvard University (USA), took a different approach: the researchers suspected that mosquitoes collected indoors may represent only a subset of the entire A. gambiae population. If true, this would mean that the standard collection method, morning collection of mosquitoes inside houses, would sample mosquitoes that bite and rest indoors, but could entirely miss mosquitoes that leave houses immediately after biting, as well as those that bite outdoors and do not even enter the house.
In large study in Burkina Faso to identify the mosquito genes that control transmission of malaria, the scientists collected mosquitoes across a 400 km region of the country over four years. They collected mosquitoes inside houses, as well as outside in pools of water close to villages. Female mosquitoes must lay their eggs in water to develop into larvae, and then adult mosquitoes. The scientists hypothesized that in West Africa’s arid savanna zone, where there are relatively few pools of water available for female mosquitoes to lay eggs, larvae collected from pools should include all mosquito groups, regardless of the adult mosquitoes’ behavioral preferences for indoor or outdoor environments.
By this means, the researchers discovered a new, previously undescribed mosquito subpopulation of A. gambiae representing more of the half of the mosquitoes sampled. The new subpopulation was named Goundry after one of the villages where they were collected. The Goundry subpopulation does not rest indoors after biting people, which explains why these mosquitoes have gone undetected through traditional sampling methods.
A genomic analysis showed that while Goundry mosquitoes belong to the A. gambiae species, they are a genetically different sub-group. In contrast to other known A. gambiae populations in the study area, Goundry mosquitoes are more susceptible to malaria parasite infection, and thus could be an especially effective vector of malaria transmission.
This surprising discovery could explain why current mosquito vector control measures directed against indoor-resting mosquitoes have not been fully effective at reducing malaria transmission. This work highlights the need to rethink malaria control strategies in light of different mosquito biting and resting behaviors, in order to target the broadest range of mosquito vectors that transmit malaria.
A cryptic subgroup of Anopheles gambiae is highly susceptible to human malaria parasites, Science, 4 février 2011.
Michelle M. Riehle (1,2,#), Wamdaogo M. Guelbeogo (3,#), Awa Gneme (3), Karin Eiglmeier (1), Inge Holm (1), Emmanuel Bischoff (1), Thierry Garnier (1), Gregory M. Snyder (2), Xuanzhong Li (4), Kyriacos Markianos (4), N’Fale Sagnon (3), Kenneth D. Vernick (1,2).
(1) Institut Pasteur, Unit of Insect Vector Genetics and Genomics, Department of Parasitology and Mycology, CNRS Unit of Hosts, Vectors and Pathogens (URA3012), Department of Environment and Sustainable Development (EDD), 28 rue du Docteur Roux, Paris 75015, FRANCE.
(2) University of Minnesota, Department of Microbiology, 1500 Gortner Avenue, Saint Paul, MN 55108, USA.
(3) Centre National de Recherche et de Formation sur le Paludisme, 1487 Avenue de l’Oubritenga, 01 BP 2208 Ouagadougou, BURKINA FASO.
(4) Program in Genomics, Children's Hospital Boston, Harvard Medical School, 3 Blackfan Street, Boston, MA 2115, USA.
# MMR et WMG ont contribué de manière équivalente à ce travail.