The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his ...
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources ...
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over ...
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial ...
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study ...
Antibiotic multiresistance: why bacteria are so effective
In an article published in Science, teams from the Institut Pasteur and the University of Limoges, associated with the CNRS and Inserm, decipher for the first time the molecular mechanism that enables bacteria to acquire multiresistance to antibiotics, and that even allows them to adapt this resistance to their environment. This discovery highlights the difficulties that will have to be tackled by public health strategies if they are to address the problems created by multiresistance.
Communiqué de presse
Paris, may 22, 2010
Multiresistance of bacteria to antibiotics is a phenomenon that appeared when these drugs began to be used in the 1950s. It was subsequently discovered that resistance genes were easily captured, disseminated and exchanged from one bacterium to another by a system involving genetic "copying and pasting" of the structures containing these genes, known as integrons. But the dynamics of these exchanges, which governs the multiresistance development in bacteria, remained unknown.
The work of researchers from the Institut Pasteur associated with the CNRS (Bacterial Genome Plasticity unit, CNRS URA 2171) and from Inserm, within the Limoges Faculty of Medicine (EA3175, Inserm, Avenir Team), in cooperation with Spanish teams, reveals for the first time today how bacteria acquire these multiresistance properties. It is actually the antibiotics themselves that trigger the synthesis of the bacterial enzyme that captures the resistance genes and enables their expression in the integron.
This enzyme also promotes the random rearrangement of the resistance genes within the integron. The order of these genes in the integron determines the degree of priority for their expression: the first are expressed most highly and give the bacteria the corresponding resistance. The last remain silent, although they are kept in reserve. When a new rearrangement occurs, triggered by taking an antibiotic, for example, they are likely to be moved to the first positions, and give the bacteria the required resistance to this drug. The bacteria with the right "combination" of genes will therefore be able to survive and ensure that the resistance potential is maintained from generation to generation.
This work shows the extent to which strategies of bacterial adaptation to antibiotics are effective, in both the short and the long term. It therefore clearly demonstrates the difficulties associated with bacterial genetics that future public health measures will have to take into account if they are to tackle the problem of multiresistance.
The SOS response controls integron recombination, Science, May 22, 2009.
Émilie Guerin(1)*, Guillaume Cambray(2)*, Neus Sanchez-Alberola(3)*, Susana Campoy(3), Ivan Erill(4), Sandra Da Re(1), Bruno Gonzalez-Zorn(5), Jordi Barbé(3), Marie-Cécile Ploy(1), Didier Mazel(2)
(1) Univ. Limoges, Faculty of Medicine, EA3175; Inserm, Avenir Team, Limoges, France
(2) Institut Pasteur, Bacterial Genome Plasticity, CNRS URA 2171, Paris, France
(3) Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Spain
(4) Biomedical Applications Group, Centro Nacional de Microelectrónica (CNM-IMB,
CSIC), Barcelona, Spain
(5) Department of Animal Health, Veterinary Faculty, Universidad Complutense de Madrid, Spain.
*Equal contribution from these authors.
Institut Pasteur Press Office
Marion Doucet ou Nadine Peyrolo – +33 (0)1 45 68 89 28 - firstname.lastname@example.org