The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
AIDS: discovery of a new mechanism induced by HIV to modulate the immune system
Researchers from the Pasteur Institute and the CNRS* have revealed a novel mechanism utilized by the AIDS virus (HIV) to modulate the host immune response. They have shown that the virus substantially reduces contacts between the HIV-1 infected T lymphocytes and other cells of the immune system. These cells contacts are crucial to the triggering of adequate immune response. Their work is published in Immunity.
Paris, june 6, 2006
The T lymphocytes, key cells in the immune system, need to come into contact with "antigen presenting cells" in order to trigger an immune response. The contact between these two cells is called an "immunological synapse".
Teams at the Pasteur Institute, led by Andrés Alcover, head of the Lymphocyte Cell Biology Unit, and by Olivier Schwartz, head of the Virus Immunity Group associated to the CNRS (URA 1930), have recently reported that this immunological synapse is a target for HIV-1.
Their work has shown that, in the T lymphocyte, HIV blocks the intracellular transport of molecules that are essential to immune synapse formation. Conclusion: contacts between the T lymphocytes and antigen presenting cells are altered. This modifies the T lymphocyte response.
The researchers have identified an HIV component, the viral protein called Nef, whose role is still poorly understood, as being responsible for this phenomenon.
Can we expect applications as a result of these advances? It is still too early to say but these researchers are continuing to decode the mechanism involved which may well, in time, offer up new therapeutic avenues to be explored.
This work was sponsored by the French National AIDS Research Agency, SIDACTION, League for the Prevention of Cancer-Paris Committee, CNRS, European Committee and Pasteur Institute.
* CNRS = French National Centre for Scientific Research
" Human Immunodeficiency Virus Type-1 Infection Impairs the Formation of the Immunological Synapse" : Immunity. 24 mai 2006
Maria Isabel Thoulouze (1,2,3,4), Nathalie Sol-Foulon (3,5), Fabien Blanchet (3), Alice Dautry-Varsat (2), Olivier Schwartz (3,6)* et Andrés Alcover (1,2,6)*
1 Unité de Biologie Cellulaire des Lymphocytes, Institut Pasteur
2 Unité de Biologie des Interactions Cellulaires, unité de recherche associée au CNRS-2582, Institut Pasteur
3 Groupe Virus et Immunité, unité associée au CNRS-1930, Institut Pasteur
4 Unité de Virologie et Immunologie Moléculaires, INRA, Jouy-en-Josas
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