The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Scientists discover a novel mechanism in the development of pre-eclampsia
No treatment currently exists for pre-eclampsia, a gestational disorder which affects over 8 million pregnant women worldwide and can cause premature delivery or death of the mother or the fetus. In a study published in the journal Antioxidants & Redox Signaling, scientists from the CNRS, Inserm, the Institut Pasteur and INRA reveal that alterations in mitochondria located in the placenta and associated with the imbalance of reactive oxygen and nitrogen species could be the underlying cause of this condition. Their fundamental research opens up possibilities for developing new biomarkers for detecting pre-eclampsia in its early stages and exploring new therapeutic approaches.
Pre-eclampsia affects roughly 5% of all pregnancies and represents a major cause of morbidity and death among mothers, fetuses and newborns. This condition is responsible for 500,000 deaths each year, primarily in developing countries. In industrialized countries, pre-eclampsia is still a potentially serious complication of pregnancy. Warning signs include hypertension, proteinuria, edema (swelling) accompanied by severe headache, abdominal pain, blurred vision, vomiting, and confusion. In cases of pre-eclampsia where the mother's life is at risk, delivery by C-section is necessary. This is often carried out as an emergency procedure, well before the end of the normal gestation period, with potentially dramatic consequences for the infant. While symptomatic treatment is available to manage hypertension, no effective treatment for pre-eclampsia currently exists. Genetic studies carried out on at-risk human populations, which led to the development of pre-eclampsia models in mice, made it possible to focus research on the role played by a new transcription factor, STOX1, in the onset of this pathological condition.
Using these models, scientists showed that mitochondrial activity and the nitroso-redox balance (the ratio between reactive species of oxygen and nitrogen) are altered in placenta cells of pre-eclamptic mice and that this is directly linked to the elevated expression of STOX1. The nitroso-redox balance controls the equilibrium between oxidative and nitrosative stress which generates high levels of toxic molecules such as superoxide and peroxynitrite, both of which are normal products of cellular metabolism at lower concentrations. The role played by STOX1 in the regulation of oxidative/nitrosative stress is strongly influenced by oxygen pressure. This pressure varies naturally during pregnancy and is linked to mitochondrial homeostasis and nitric oxide (NO) metabolism. Nitric oxide is essential for vasodilation (the widening of blood vessels) and blood pressure regulation. When pre-eclampsia is induced by the over expression of STOX1, the nitroso-redox balance in the placenta is disrupted, resulting in a deficit of NO for the mother and impairing the response to physiological changes in oxygen pressure. This novel mechanism could explain the characteristic symptoms brought on by pre-eclampsia, in particular hypertension, proteinuria and increased oxidative stress.
This research opens up the possibility of characterizing new molecular markers for early-stage pre-eclampsia and developing therapeutic strategies that target the nitroso-redox balance, mitochondria, and nitric oxide metabolism.