En raison du plan vigie pirate, l'accès à l'Institut Pasteur est subordonné à la présentation d'une pièce d'identité

Revisiting the mechanism of common fragile sites instability
Michelle DEBATISSE
Directrice de l'Unité Dynamique de l'information génétique : bases fondamentales et cancer
Institut Curie
Séminaire Départemental Génomes et Génétique
Salle Jean-Paul Aubert, rdc du bâtiment Fernbach - jeudi 24 mai 2012 11:00

Contact: Guy-Franck Richard (guy-franck.richard@pasteur.fr)


"How do dopamine neurons compute reward prediction error signals ?"
Pr Naoshige Ushida, PhD
Associate Professor, Center for Brain Science, Dpt of Molecular & Cellular Biology, Harvard University, Cambridge, MA, USA
Salle Jules Bordet, rdc du bâtiment Metchnikoff - jeudi 24 mai 2012 12:00

Contact: Pierre-Marie Lledo et Mariana Alonso (mariana.alonso@pasteur.fr)


Structural Mapping of the Protein Universe; One Cell at a Time
Dorit HANEIN
Sanford Burnham Medical Research Institute, La Jolla, USA

SEMINAIRE DU DEPARTEMENT DE VIROLOGIE
Salle Jean-Paul Aubert, rdc du bâtiment Fernbach - jeudi 24 mai 2012 12:30

Contact: Félix Rey (rey@pasteur.fr)


De la création des écoles vétérinaires pour combattre la peste bovine, à son éradication : 1761 - 2011
Jean-Claude Manuguerra
Institut Pasteur - Paris
Salle Jules Bordet, rdc du bâtiment Metchnikoff - jeudi 24 mai 2012 14:00

Contact: Annick OPINEL et Michel GARENNE (annick.opinel@pasteur.fr ; michel.garenne@pasteur.fr)


The molecular interplay between bacteriophages and hosts : A matter of divirusity
Rob LAVIGNE
Division of Gene Technology, Katholieke Universiteit Leuven, Belgium

Séminaire organisé par le département de Microbiologie

Abstract :
Through evolution, bacterial viruses have co-evolved with their host, resulting in a close molecular interaction during the bacteriophage
infection cycle. After ejection of phage DNA into the host bacterium, intracellular phage development entails a number of tightly programmed steps, which finally result in lysis of the host, induced by phage-encoded cell wall hydrolases. The transition to a phage-oriented
bacterial metabolism early in infection is mediated by proteins that either inhibit or co-opt critical bacterial metabolic processes to
ensure proper viral development. For this, phages encode a wealth of mostly unknown proteins.
We currently investigate these molecular hijacking and lysis processes in Pseudomonas infecting phages, using the "-omics" approaches to better understand the fundamental biology of this interplay. From an applied perspective, we aim to "harvest" novel enzymes and relevant proteins for medical, biotechnological and industrial applications.
Salle Jean-Paul Aubert, rdc du bâtiment Fernbach - vendredi 25 mai 2012 11:30

Contact: Laurent Debarbieux (laurent.debarbieux@pasteur.fr)


Steroid hormone signalling and hemocyte activation in Drosophila
Antonio JACINTO
Instituto de Medicina Molecular, Portugal
Amphithéâtre Jacques Monod, sous-sol bâtiment Jacques Monod - vendredi 25 mai 2012 12:00

Contact: Jean-Pierre LEVRAUD (jean-pierre.levraud@pasteur.fr)


Pharmacological silencing of HIV transcription
Susana Valente
The Scripps Research Institute, Florida USA

SEMINAIRE DU DEPARTEMENT DE VIROLOGIE
Salle 014-015, rdc du bâtiment Lwoff - mercredi 30 mai 2012 12:00

Contact: Olivier Schwartz (schwartz@pasteur.fr)


Critical role for LFA1 in T cell exhaustion and protection against a chronic viral infection
Antonio PEIXOTO
Department of Molecular Mechanisms of Mycobacterial Infections - UMR 5089 CNRS/UPS
Institut de Pharmacologie et de Biologie Structurale – Toulouse
SEMINAIRE DU DEPARTEMENT GENOMES ET GENETIQUE
Salle Jean-Paul Aubert, rdc du bâtiment Fernbach - jeudi 31 mai 2012 11:00

Contact: Ludovic Tailleux (ludovic.tailleux@pasteur.fr)


New ABC transporters in Leishmania: involvement in the infectivity and drug resistance
Francisco Gamarro Conde
Instituto de Parasitologia y Biomedicina "Lopez-Neyra"
CSIC
Grenade - Espagne
Salle 014-015, rdc du bâtiment Lwoff - jeudi 31 mai 2012 12:00

Contact: Gérald Spaeth (gerald.spaeth@pasteur.fr)


" Lipids Turn On Protein Kinases "
Dr Thomas LEONARD
Department of Structural and Computational Biology, Max F. Perutz Laboratories, Vienna

( ** Séminaire du Département de Biologie Structurale et Chimie / DBSC ** )
Amphithéâtre Jacques Monod, sous-sol bâtiment Jacques Monod - jeudi 31 mai 2012 12:00

Contact: Ludovic Sauguet - Pierre Maisonneuve (ludovic.sauguet@pasteur.fr - pierre.maisonneuve@pasteur.fr)


Salmonella secretion systems related to colonization and infection of poultry
Wolfgang KÖSTER
Vaccine and Infectious Disease Organization – International Vaccine Center,
University of Saskatchewan, Canada

Séminaire organisé par le Département de Microbiologie

Abstract

Salmonella enterica subspecies enterica serovar Enteritidis (Salmonella Enteritidis) is a leading causative agent of gastroenteritis in humans. This pathogen also colonizes the intestinal tract of poultry and can spread systemically in chickens. Transfer to humans usually occurs through undercooked or improperly handled poultry meat or eggs. Salmonella Enteritidis employs two Type III Secretion systems (T3SS) which deliver so-called effector proteins directly into host cells. T3SS-1, T3SS-2 are located on Salmonella Pathogenicity Islands, SPI-1 and SPI-2. The bacterial twin-arginine transport (Tat) pathway is responsible for the translocation of folded proteins across the cytoplasmic membrane. In order to study the roles of T3SS-1, T3SS-2 and the Tat system in infection and colonization of Salmonella Enteritidis in chickens, we constructed chromosomal deletion mutantions in genes, which are essential components of these systems. When tested in chickens, the Tat system inactivation did not substantially affect cecal colonization, but it delayed systemic infection. Similar observations were made testing SPI-1 and SPI-2 mutants. Altogether, our data demonstrated that all three systems might play a role in Salmonella Enteriditis pathogenesis.
Salle Jean-Paul Aubert, rdc du bâtiment Fernbach - jeudi 31 mai 2012 14:00

Contact: Elie Dassa (elie.dassa@pasteur.fr)


How to orchestrate assembly of prokaryotic molybdoenzymes
Axel MAGALON
Laboratoire de Chimie Bactérienne (UMR 7283) CNRS - Institut de Microbiologie de la Méditerranée - Aix-Marseille Université

Séminaire organisé par le département de Microbiologie

Abstract
Transition metals play a critical role in the functioning of numerous proteins and enzymes. In order for metals to play their essential roles, they must be acquired, assembled into proper cofactors, and appropriately incorporated into their target enzymes, all while avoiding the toxicity associated with free metals; these are complicated processes typically requiring a large number of gene products. While some of the gene products involved in metalloenzyme maturation are part of the general house-keeping machinery of a cell, others have functions unique to the maturation of a single metalloenzyme.
One of the most prominent example is molybdenum, a transition metal found associated to a pterin-based cofactor being as such part of the active site of a wide variety of enzymes present in all domains of life. The importance of those molybdenum pterin cofactor-containing enzymes is exemplified by their ubiquity, their roles in metabolic diversity and global geochemical cycles.
Based on recent studies from our group as well as others, significant progresses have been made toward understanding the assembly of folded and active prokaryotic molybdoenzymes. Expression of prokaryotic molybdoenzymes is controlled by transport of Mo or W (often replacing Mo in the cofactor) into the cell, cofactor biosynthesis, transcriptional regulation of apo-protein expression and riboswitch mechanisms. The biosynthesis of prokaryotic molybdoenzymes is an intricate process, requiring the synthesis of various subunits in the cytoplasm, incorporation of the metal and pterin cofactors, subunit assembly, correct subcellular targeting/transport and in many cases anchoring of the complex to the inner membrane. A series of devoted molybdoenzyme maturation proteins are crucial in various stages of enzyme maturation. Interaction with a specific lipid constitutes, in some cases, the final biogenesis step and is required for activity of the membrane-bound molybdoenzyme. Finally, compartmentalization of respiratory processes in “respirazones” could be achieved through a tightly controlled subcellular localization of individual respiratory complexes.
During this talk, I will highlight the progress on prokaryotic molybdoenzyme assembly which has been done through the concerted and joined efforts from researchers in biology, chemistry and physics.
Salle Jean-Paul Aubert, rdc du bâtiment Fernbach - vendredi 1 juin 2012 11:30

Contact: Cécile Wandersman (cecile.wandersman@pasteur.fr)


The Drosophila intestinal epithelium : from immunity to physiology
Bruno LEMAITRE
UPLEM, École Polytechnique Fédérale de Lausanne (EPFL), Swiss
Amphithéâtre Jacques Monod, sous-sol bâtiment Jacques Monod - vendredi 1 juin 2012 12:00

Contact: Benoit ROBERT (benoit.robert@pasteur.fr)


Regulation of actin and plasma membrane dynamics by BAR domain proteins
Prof. Pekka LAPPALAINEN
Institute of Biotechnology
P.O. Box 56
00014 University of Helsinki
Finland

Séminaire du Département de Biologie Cellulaire et Infection
Amphithéâtre Jacques Monod, sous-sol bâtiment Jacques Monod - lundi 4 juin 2012 12:00

Contact: Nathalie Sauvonnet (nathalie.sauvonnet@pasteur.fr)


Novel functions of sphingosine-1-phosphate in neuroinflammation
Tomasz KORDULA
Virginia Commonwealth University School of Medicine, Etats-Unis.
Salle Jules Bordet, rdc du bâtiment Metchnikoff - lundi 4 juin 2012 12:00

Contact: Sandra Pellegrini (sandra.pellegrini@pasteur.fr)


" Towards understanding the two-membrane spanning type 2 secretion system "
Prof. Wim HOL
Professor of Biochemistry and Biological Structure
Head, Biomolecular Structure Center
University of Washington - Seattle
Amphithéâtre Jacques Monod, sous-sol bâtiment Jacques Monod - mercredi 6 juin 2012 12:00

Contact: Rémi FRONZES & Olivera FRANCETIC (remi.fronzes@pasteur.fr - olivera.francetic@pasteur.fr)


Gene regulation in three dimensions
Wouter DE LAAT
Hubrecht Institute, Utrecht The Netherlands
SEMINAIRE DU DEPARTEMENT GENOMES ET GENETIQUE
Salle Jean-Paul Aubert, rdc du bâtiment Fernbach - jeudi 7 juin 2012 11:00

Contact: Emmanuelle Fabre et Jost Enninga (emmanuelle.fabre@pasteur.fr jost.enninga@pasteur.fr)


" Structural Biology in Drug Design of Tropical Parasitic Diseases "
Prof. Wim HOL
Professor of Biochemistry and Biological Structure
Head, Biomolecular Structure Center
University of Washington - Seattle
Amphithéâtre Jacques Monod, sous-sol bâtiment Jacques Monod - jeudi 7 juin 2012 11:30

Contact: Rémi FRONZES - Geneviève MILON (remi.fronzes@pasteur.fr - genevieve.milon@pasteur.fr)


Eradication et décision en santé publique : quels critères prendre en compte ? exemple de la rage
Florence RIBADEAU DUMAS
Institut Pasteur - Paris
Salle Jules Bordet, rdc du bâtiment Metchnikoff - jeudi 7 juin 2012 14:00

Contact: Annick OPINEL et Michel GARENNE (annick.opinel@pasteur.fr ; michel.garenne@pasteur.fr)


Two-Partner Secretion in Bordetella : the FHA/FhaC model
Centre d'Infection et d'Immunité de Lille - CNRS UMR 8204 - INSERM U1019 – Institut Pasteur de Lille - Université Lille-Nord de France

Séminaire organisé par le Département de Microbiologie

Abstract
Two-Partner Secretion (TPS) systems are widespread among Gram-negative bacteria. They are dedicated to the secretion of ‘TpsA’ proteins that fold as long beta helices and carry out various functions in their host organisms. These proteins cross the plasma membrane in a Sec-dependent fashion and then are translocated across the outer membrane by a specific transporter of the Omp85/TpsB superfamily. In the whooping cough agent Bordetella pertussis, the FHA adhesin is secreted by the transporter FhaC, a member of the Omp85/TpsB superfamily. Our goal is to decipher the molecular principles that govern two-partner secretion using the FHA/FhaC model system. A conserved domain in FHA has been identified that is likely to initiate the vectorial folding of the protein at the cell surface. We have shown that the chaperone /protease DegP is involved in FHA secretion in B. pertussis. FhaC forms a 16-stranded beta barrel in the outer membrane that is obstructed in the form that was crystallized. We have obtained evidence for an important conformational change that opens the channel.
Salle Jean-Paul Aubert, rdc du bâtiment Fernbach - vendredi 8 juin 2012 11:30

Contact: Olivera Francetic (olivera.francetic@pasteur.fr)


Immunity and Immunopathology in experimental Malaria
Jean LANGHORNE
MRC National Institute for Medical Research, London, Grande-Bretagne
Salle Jules Bordet, rdc du bâtiment Metchnikoff - vendredi 8 juin 2012 12:00

Contact: Paulo Vieira (paulo.vieira@pasteur.fr)


Tissue refinement - from disorder to order
Buzz BAUM
Cancer Research UK Senior Research Fellow - MRC - Laboratory of Molecular Cell Biology, United Kingdom
Amphithéâtre Jacques Monod, sous-sol bâtiment Jacques Monod - vendredi 8 juin 2012 12:00

Contact: François SCHWEISGUTH (francois.schweisguth@pasteur.fr)


Regulatory B10 cells in inflammation, autoimmunity and cancer
Thomas TEDDER
Duke university School of Medicine, Durham, Etats-Unis
Salle Jules Bordet, rdc du bâtiment Metchnikoff - vendredi 8 juin 2012 16:00

Contact: Alexander Tang (alexander.tang@pasteur.fr)


Neural stem and progenitor cells and the evolution of the cerebral cortex
Pr. Wieland B. HUTTNER
Max-Planck-Institute of Molecular Cell Biology and Genetics
Dresden, Germany

Séminaire du Département de Biologie Cellulaire et Infection
Amphithéâtre Jacques Monod, sous-sol bâtiment Jacques Monod - lundi 11 juin 2012 12:00

Contact: Arnaud Echard (arnaud.echard@pasteur.fr)


" Imaging Biological Function in 3D Across Scales: From Macromolecules to Cells to Tissues and Microbial communities "
Manfred AUER
Lawrence Berkeley National Laboratory, Berkeley

( ** Séminaire du Département de Biologie Structurale et Chimie / DBSC ** )
Amphithéâtre Jacques Monod, sous-sol bâtiment Jacques Monod - mercredi 13 juin 2012 12:00

Contact: Michael NILGES (michael.nilges@pasteur.fr)


Fundamental and applied aspects of lambda Red homologous recombination
Francis STEWART
Genomics, Technische Universitaet Dresden
Séminaire du Département Génomes et Génétique
Salle Jean-Paul Aubert, rdc du bâtiment Fernbach - jeudi 14 juin 2012 11:00

Contact: Didier Mazel (didier.mazel@pasteur.fr)


" Molecular recognition at protein surfaces "
Ernest GIRALT
Institute for Research in Biomedicine, Parc Cientific de Barcelona

( ** Séminaire du Département de Biologie Structurale et Chimie / DBSC ** )
Amphithéâtre Jacques Monod, sous-sol bâtiment Jacques Monod - jeudi 14 juin 2012 12:00

Contact: Muriel DELEPIERRE (muriel.delepierre@pasteur.fr)


Role of basophils in protective immunity against parasitic infection and in allergy.
Hajime KARASUYAMA
Tokyo Medical and Dental university, Tokyo, Japon
Salle Jules Bordet, rdc du bâtiment Metchnikoff - jeudi 14 juin 2012 13:00

Contact: Pierre Bruhns (pierre.bruhns@pasteur.fr)


Les femmes pasteuriennes : de la « cuisine » à la paillasse
Sandra Legout
bibliothécaire- responsable du fonds patrimonial- Médiathèque Pasteur

Dés 1889, les femmes sont présentes dans les laboratoires pasteuriens. D’abord « petites mains dans les cuisines » puis préparatrices, assistantes, elles vont lentement s’imposer dans l’univers de la recherche scientifique pasteurienne jusqu’à diriger des laboratoires.
Rencontre avec les premières femmes scientifiques pasteuriennes …
Musée de l'Institut Pasteur - jeudi 14 juin 2012 15:00

Contact: Mueil Hilaire


Regulation of cell division by Polo and Aurora family kinases
Pr. Francis BARR
EP Abraham Professor of Mechanistic Cell Biology
Department of Biochemistry, University of Oxford

Séminaire du Département de Biologie Cellulaire et Infection
Amphithéâtre Jacques Monod, sous-sol bâtiment Jacques Monod - lundi 18 juin 2012 12:00

Contact: Arnaud Echard et Robert Weil (arnaud.echard@pasteur.fr, robert.weil@pasteur.fr)


Lynn Margulis and the endosymbiotic origin of eukaryotes: a historical reevaluation
Antonio Lazcano
Facultad de Ciencias, UNAM, Mexico
Salle Jean-Paul Aubert, rdc du bâtiment Fernbach - lundi 18 juin 2012 14:00

Contact: Miria Ricchetti (mricch@pasteur.fr)


Chimiothèques locale, nationale, européenne, à propos de la chimiothèque du CERMN et de ses contes
Prof. Sylvain RAULT
Centre d'Etudes et de Recherche sur le Médicament de Normandie, Université de Caen Basse-Normandie

( ** Séminaire du Département de Biologie Structurale et Chimie / DBSC ** )
Amphithéâtre Jacques Monod, sous-sol bâtiment Jacques Monod - mardi 19 juin 2012 12:00

Contact: Thérèse MALLIAVIN (therese.malliavin@pasteur.fr)


Controlling the indeterminate : prospectives on Hepatitis B and childhood vaccination in West and Central Africa
Tamara GILES-VERNICK
Institut Pasteur - Paris
Salle Jules Bordet, rdc du bâtiment Metchnikoff - jeudi 21 juin 2012 14:00

Contact: Annick OPINEL et Michel GARENNE (annick.opinel@pasteur.fr ; michel.garenne@pasteur.fr)


" " Characterisation of the FhuA-pb5 complex: interaction between an E. coli outer-membrane transporter and the Receptor Binding Protein of phage T5 "
Cécile BREYTON
Institut de Biologie Structurale, UMR 5075 CNRS/CEA/UJF, Grenoble

( ** Séminaire du Département de Biologie Structurale et Chimie / DBSC ** )
Salle 014-015, rdc du bâtiment Lwoff - jeudi 28 juin 2012 14:00

Contact: Nadia IZADI-PRUNEYRE (<mailto:nadia.izadi@pasteur.fr>nadia.izadi@pasteur.fr)


Chromatin dynamics and function
Department of Cell Biology and Infection - Mini-Symposium
Institut Pasteur
Department of Cell Biology and Infection

Mini-symposium

Auditorium du Centre d’Information Scientifique

14:00-14:45: Dirk Schübeler (Friedrich Miescher Institute, Basel, Switzerland)
DNA sequence determinants of gene repression

14:45-15:10: Romain Koszul (Institut Pasteur, Spatial Regulation of Genomes)
Capturing and modeling yeast chromosome organization in wild type and structural mutants

15:10-15:35: Christian Muchardt (Institut Pasteur, Epigenetic Regulation)
Human nuclear Argonaute couples chromatin-mediated silencing to regulation of alternative splicing

15:35-16:00: Oliver Bischof (Institut Pasteur, Nuclear Organisation and Oncogenesis)
The long and the short reach of noncoding RNAs in cellular senescence

16:00-16:30: Coffee break

16:30-16:55: Sarra Merzouk (Institut Pasteur, Mouse Molecular Genetics)
Gene expression and chromatin folding at the X-inactivation center during imprinted X-chromosome inactivation

16:55-17:20: Hélène Bierne (Institut Pasteur, Bacteria-Cell Interactions)
An epigenetic regulator targeted by a bacterial pathogen: the dark side of the BAHD1 chromatin-silencing complex

17:20-17:45: Laurence Arbibe (Institut Pasteur, Molecular Microbial Pathogenesis)
The interception of MAPK nuclear signaling by Shigella: impact on chromatin information during transcription of immune genes

17:45-18:30: Geneviève Almouzni (Institut Curie, Nuclear dynamics and genome plasticity)
Variation on chromatin assembly from the nucleosome to higher order organization

18:30-19:00: Cocktail
Salle de Conférence du CIS (auditorium) - samedi 30 juin 2012 14:00

Contact: Anne Dejean et Christophe Zimmer (lambrech@pasteur.fr)


Small RNA-directed control of the plant and animal innate immune responses
Lionel NAVARRO, C.R. CNRS
Institut de Biologie,
ENS, Paris, France

Séminaire du Département de Biologie Cellulaire et Infection
Amphithéâtre Jacques Monod, sous-sol bâtiment Jacques Monod - lundi 29 octobre 2012 12:00

Contact: Philippe Sansonetti (philippe.sansonetti@pasteur.fr)